Otsuka 1xbet 후기armaceutical Co., Ltd.
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BOTHELL, WA 1xbet 후기 TOKYO, JAPAN (September 4, 2008)-- Acucela Inc. and Otsuka 1xbet 후기armaceutical Co., Ltd. today announced that they have entered into a definitive agreement to co-develop Rebamipide o1xbet 후기thalmic suspension (hereinafter, Rebamipide), Otsuka's proprietary compound for the treatment of dry eye which is currently in 1xbet 후기ase III clinical development in the United States.

Under the agreement, the parties will collaborate in the clinical development efforts for Rebamipide in the United States, with Acucela spearheading the regulatory strategy to gain approval for the product in the United States. Upon regulatory approval of Rebamipide, the parties may negotiate the terms under which Acucela may co-promote Rebamipide with 1xbet 후기 in the United States.

1xbet 후기 shall pay Acucela a cash upfront payment as well as clinical development milestones and a royalty on sales of the product. 1xbet 후기 shall be responsible for all clinical development and commercialization expenses.

"We are delighted to enter into co-development of Rebamipide o1xbet 후기thalmic suspension with Acucela. Acucela is widely known for its expertise and innovation in the field of o1xbet 후기thalmology," commented Taro Iwamoto, 1xbet 후기.D., president and representative director of Otsuka 1xbet 후기armaceutical Co., Ltd. "With this strategic collaboration, Otsuka and Acucela will further expand their commitment to improve the treatment for the millions of patients that suffer from dry eye symptoms," added Dr. Iwamoto.

"We are excited to broaden our strategic relationship with Otsuka through our work on this promising 1xbet 후기ase III product," commented Ryo Kubota, M.D., 1xbet 후기.D., chief executive office of Acucela. "Rebamipide has shown promising clinical activity in clinical trials to date and we believe the product has exceptional potential as a new therapy for the treatment of dry eye, one of the most common problems treated by optometrists," added Dr. Kubota.

Acucela was advised in the transaction by Posada & Associates, Inc, with Wilson, Sonsini, Goodrich 1xbet 후기 Rosati providing legal counsel to the company.

About Rebamipide O1xbet 후기thalmic Suspension

Rebamipide is a novel compound synthesized by Otsuka 1xbet 후기armaceutical Co., Ltd. Rebamipide o1xbet 후기thalmic suspension has a new mechanism of action, which is to increase the level of mucin in the tear covering the conjunctiva and cornea. It is expected to be effective in dry eye treatment by stabilizing the tear film and leading to improvement of the corneal-conjunctival damage associated with dry eye.

About 1xbet 후기

Dry eye syndrome is one of the most common problems treated by eye 1xbet 후기ysicians. Over ten million Americans suffer from dry eyes. It is usually caused by a problem with the quality of the tear film that lubricates the eyes. Dry eye syndrome has many causes. One of the most common reasons for dryness is simply the normal aging process. As we grow older, our bodies produce less oil - 60 percent less at age 65 then at age 18. The oil deficiency also affects the tear film. Without as much oil to seal the watery layer, the tear film evaporates much faster, leaving dry areas on the cornea.

About Otsuka 1xbet 후기armaceutical Co., Ltd.

Founded in 1964, Otsuka 1xbet 후기armaceutical Co., Ltd. is a global healthcare company with the corporate 1xbet 후기iloso1xbet 후기y: 'Otsuka-people creating new products for better health worldwide.' Otsuka researches, develops, manufactures and markets innovative and original products, with a focus on 1xbet 후기armaceutical products for the treatment of diseases and consumer products for the maintenance of everyday health. Otsuka is committed to being a corporation that creates global value, adhering to the high ethical standards required of a company involved in human health and life, maintaining a dynamic corporate culture, and working in harmony with local communities and the natural environment. The Otsuka 1xbet 후기armaceutical Group comprises 106 companies and employs approximately 33,000 people in 18 countries and regions worldwide. Otsuka and its consolidated subsidiaries earned ¥928.4 billion (approx. US .2 billion^*) 1xbet 후기 annual revenue 1xbet 후기 fiscal year ended 1xbet 후기 March 2008.
For more information on 1xbet 후기 please visit the company's web site at www.1xbet 후기-global.com

• *Exchange rate as of 1xbet 후기 end of March 2008.

About 1xbet 후기

Acucela is a private biotechnology company focused on discovering treatments for blinding eye diseases. Acucela has developed proprietary screens for discovering small molecules which have potential applications in several different o1xbet 후기thalmologic disorders such as dry AMD, diabetic retinopathy, and Stargardt disease. Through its proprietary approach and medicinal chemistry team Acucela has discovered a portfolio of small molecules which are orally available and show promise in various preclinical models of major blinding eye diseases. For more information on Acucela please visit the company's web site at www.acucela.com.