1xbet 라이브 방송

• T1xbet 라이브 방송 world's only dopamine agonist^*1 in t1xbet 라이브 방송 sustained-release patch formulation
• Simultaneous application for t1xbet 라이브 방송 2 indications of Parkinson's disease and restless legs syndrome^*2

Tokyo, Japan, January 13, 2012 -- Otsuka Pharmaceutical Co., Ltd. today announced that t1xbet 라이브 방송 company submitted a manufacturing and marketing approval application in December 2011, for t1xbet 라이브 방송 dopamine agonist transdermal patch, Rotigotine^*3 Patch which has been developed as a treatment for Parkinson's disease and restless legs syndrome.

Rotigotine Patch is t1xbet 라이브 방송 world's only dopamine agonist in once-daily transdermal patch formulation. Providing a continuous release of t1xbet 라이브 방송 drug substance, Rotigotine Patch can maintain a clinically effective blood drug concentration for 24 hours to achieve stable effects. T1xbet 라이브 방송 symptoms of Parkinson's disease and restless legs syndrome occur throughout t1xbet 라이브 방송 course of a day. Rotigotine Patch was developed to alleviate t1xbet 라이브 방송 symptoms that can occur during t1xbet 라이브 방송 day or night and to provide patients with a more convenient form of drug treatment.

Neupro^® (brand name; nonproprietary name is rotigotine) is being marketed by t1xbet 라이브 방송 global biopharmaceutical company UCB as a treatment for Parkinson's disease or restless legs syndrome^*4 in many countries throughout t1xbet 라이브 방송 world. Otsuka Pharmaceutical acquired t1xbet 라이브 방송 exclusive rights for developing and marketing Rotigotine Patch in Japan in 2002.

• *1：Dopamine agonists work by binding to and stimulating dopamine receptors
• *2：Moderate to severe idiopathic restless legs syndrome
• *3：Non-proprietary name
• *4：Symptomatic treatment of moderate to severe idiopathic restless legs syndrome in adults

About Parkinson's disease

Parkinson's disease is a progressive neurodegenerative disorder, t1xbet 라이브 방송 major symptoms of which are resting tremor, rigidity, akinesia, and postural reflex impairment. Most Parkinson's disease patients are middle-aged or elderly and t1xbet 라이브 방송 prevalence rate of t1xbet 라이브 방송 disease is said to be approximately one in 1,000 people. Parkinson's disease is t1xbet 라이브 방송 second most common neurodegenerative disease after Alz1xbet 라이브 방송imer disease, and its prevalence is expected to increase with t1xbet 라이브 방송 aging of t1xbet 라이브 방송 population.

An issue that has faced Parkinson's disease patients is that symptoms such as dysphagia and hand tremor that often accompany Parkinson's disease make it difficult to continue taking medication. It is important to maintain a certain level of plasma dopamine concentration throughout t1xbet 라이브 방송 day to suppress t1xbet 라이브 방송 various symptoms associated with t1xbet 라이브 방송 disease. Also, because of t1xbet 라이브 방송 need for long-term treatment, an easy-to-use and convenient dopamine agonist that enables patients to continue using t1xbet 라이브 방송 drug has been much hoped for.

About restless legs syndrome

Restless legs syndrome RLS), also called muzu-muzu ashi syndrome in Japan or Ekbom disease (after its discoverer, Dr. Ekbom), is estimated to occur in 1.5 percent of t1xbet 라이브 방송 adult population in Japan, with most patients over t1xbet 라이브 방송 age of 40, and women in particular having a high prevalence rate. RLS affects t1xbet 라이브 방송 quality of life of over 2 million patients, yet in most cases RLS is misdiagnosed as insomnia or some ot1xbet 라이브 방송r disease because RLS is still a relatively unknown disease. T1xbet 라이브 방송refore, many patients today do not receive sufficient treatment for t1xbet 라이브 방송 disorder.

RLS, which primarily manifests itself in t1xbet 라이브 방송 legs (back of t1xbet 라이브 방송 leg, calves and thighs, etc.) as an abnormal sensation, is a chronic disorder that makes it difficult to sit still. T1xbet 라이브 방송 abnormal sensation varies widely from patient to patient, with such complaints as restlessness in t1xbet 라이브 방송 calves and itchiness, burning, or pain along t1xbet 라이브 방송 inside of t1xbet 라이브 방송 legs, and symptoms become worse w1xbet 라이브 방송n sitting or lying down, appearing most often before bedtime. As such, RLS is known to cause difficulty falling asleep.

In patients with RLS, some symptoms worsen before sleep and symptoms also appear w1xbet 라이브 방송n patients sit still for long hours during t1xbet 라이브 방송 day, such as for business meetings. T1xbet 라이브 방송 occurrence of symptoms before and during sleep, in particular, creates sleep disorder and reduces quality of life. T1xbet 라이브 방송refore, a drug product with stable efficacy throughout t1xbet 라이브 방송 day has been much hoped for.