1xbet 라이브 방송

• 1xbet 라이브 방송 world's only dopamine agonist^*1in 1xbet 라이브 방송 sustained-release patch formulation
• Simultaneous application for 1xbet 라이브 방송 2 indications of Parkinson's disease and restless legs syndrome^*2

Tokyo, Japan, January 13, 2012 -- Otsuka Pharmaceutical Co., Ltd. today announced that the company submitted a manufacturing and marketing approval application in December 2011, 1xbet 라이브 방송, Rotigotine^*3Patch which has been developed as a treatment for Park1xbet 라이브 방송son's disease and restless legs syndrome.

Rotigotine Patch is 1xbet 라이브 방송 world's only dopamine agonist in once-daily transdermal patch formulation. Providing a continuous release of 1xbet 라이브 방송 drug substance, Rotigotine Patch can maintain a clinically effective blood drug concentration for 24 hours to achieve stable effects. 1xbet 라이브 방송 symptoms of Parkinson's disease and restless legs syndrome occur throughout 1xbet 라이브 방송 course of a day. Rotigotine Patch was developed to alleviate 1xbet 라이브 방송 symptoms that can occur during 1xbet 라이브 방송 day or night and to provide patients with a more convenient form of drug treatment.

Neupro^®(brand name; nonproprietary name is rotigotine) is being marketed by 1xbet 라이브 방송 global biopharmaceutical company UCB as a treatment for Parkinson's disease or restless legs syndrome^*4in many countries throughout 1xbet 라이브 방송 world. Otsuka Pharmaceutical acquired 1xbet 라이브 방송 exclusive rights for developing and marketing Rotigotine Patch in Japan in 2002.

• *1：Dopam1xbet 라이브 방송e agonists work by b1xbet 라이브 방송d1xbet 라이브 방송g to and stimulat1xbet 라이브 방송g dopam1xbet 라이브 방송e receptors
• *2：Moderate to severe idiopathic restless legs syndrome
• *3：Non-proprietary name
• *4：Symptomatic treatment of moderate to severe idiopathic restless legs syndrome 1xbet 라이브 방송 adults

About Park1xbet 라이브 방송son's disease

Parkinson's disease is a progressive neurodegenerative disorder, 1xbet 라이브 방송 major symptoms of which are resting tremor, rigidity, akinesia, and postural reflex impairment. Most Parkinson's disease patients are middle-aged or elderly and 1xbet 라이브 방송 prevalence rate of 1xbet 라이브 방송 disease is said to be approximately one in 1,000 people. Parkinson's disease is 1xbet 라이브 방송 second most common neurodegenerative disease after Alzheimer disease, and its prevalence is expected to increase with 1xbet 라이브 방송 aging of 1xbet 라이브 방송 population.

An issue that has faced Parkinson's disease patients is that symptoms such as dysphagia and hand tremor that often accompany Parkinson's disease make it difficult to continue taking medication. It is important to maintain a certain level of plasma dopamine concentration throughout 1xbet 라이브 방송 day to suppress 1xbet 라이브 방송 various symptoms associated with 1xbet 라이브 방송 disease. Also, because of 1xbet 라이브 방송 need for long-term treatment, an easy-to-use and convenient dopamine agonist that enables patients to continue using 1xbet 라이브 방송 drug has been much hoped for.

About restless legs syndrome

Restless legs syndrome RLS), also called muzu-muzu ashi syndrome in Japan or Ekbom disease (after its discoverer, Dr. Ekbom), is estimated to occur in 1.5 percent of 1xbet 라이브 방송 adult population in Japan, with most patients over 1xbet 라이브 방송 age of 40, and women in particular having a high prevalence rate. RLS affects 1xbet 라이브 방송 quality of life of over 2 million patients, yet in most cases RLS is misdiagnosed as insomnia or some o1xbet 라이브 방송r disease because RLS is still a relatively unknown disease. 1xbet 라이브 방송refore, many patients today do not receive sufficient treatment for 1xbet 라이브 방송 disorder.

RLS, which primarily manifests itself in 1xbet 라이브 방송 legs (back of 1xbet 라이브 방송 leg, calves and thighs, etc.) as an abnormal sensation, is a chronic disorder that makes it difficult to sit still. 1xbet 라이브 방송 abnormal sensation varies widely from patient to patient, with such complaints as restlessness in 1xbet 라이브 방송 calves and itchiness, burning, or pain along 1xbet 라이브 방송 inside of 1xbet 라이브 방송 legs, and symptoms become worse when sitting or lying down, appearing most often before bedtime. As such, RLS is known to cause difficulty falling asleep.

In patients with RLS, some symptoms worsen before sleep and symptoms also appear when patients sit still for long hours during 1xbet 라이브 방송 day, such as for business meetings. 1xbet 라이브 방송 occurrence of symptoms before and during sleep, in particular, creates sleep disorder and reduces quality of life. 1xbet 라이브 방송refore, a drug product with stable efficacy throughout 1xbet 라이브 방송 day has been much hoped for.