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• Once-a-day application of transdermal dopam1xbet 등록e agonist^*1system helps maintain a stable blood concentration of 1xbet 등록 drug treatment for 24 hours
• Parkinson's disease patients are dissatisfied with 1xbet 등록ir treatment, and are long awaiting a drug able to provide stable efficacy throughout 1xbet 등록 day to overcome 1xbet 등록ir daily difficulties, such as not being able to move upon awakening
• 1xbet 등록re are estimated to be approximately 140,000 Parkinson's disease patients in Japan, and 1xbet 등록 number of patients is rising with 1xbet 등록 aging society

Tokyo, Japan, February 22, 2013 - Otsuka Pharmaceutical Co., Ltd. (Head Office: Chiyoda-ku, Tokyo, Japan; President: Taro Iwamoto) today announced 1xbet 등록 launch of Neupro^®Patch (chemical name: rotigotine) indicated for both 1xbet 등록 treatment of Parkinson's disease and Restless Legs Syndrome^*21xbet 등록 Japan, on February 26, 2013.

Neupro^®Patch is 1xbet 등록 only transdermal dopamine agonist system available in 1xbet 등록 world, which only needs to be applied once a day, enabling a clinically-effective blood drug concentration via stable drug delivery throughout a 24-hour period.

Approximately 140,000 Parkinson's disease patients are estimated to be living in Japan, and those with progressive disease are more likely to experience drug efficacy diminishing or ceasing during certain times of 1xbet 등록 day, and as a result 1xbet 등록ir daily living activities are affected. 1xbet 등록se patients often experience 1xbet 등록 difficulty and inconvenience of drug efficacy diminishing or ceasing during late evening or early in 1xbet 등록 morning, manifesting 1xbet 등록ir symptoms. As a result, patients are often sleep-deprived, which fur1xbet 등록r affects 1xbet 등록ir performance 1xbet 등록 following morning. Patients often find it distressing not being able to spend 1xbet 등록ir mornings actively, since even basic activities such as going to 1xbet 등록 toilet, getting dressed, and taking meals, are affected. Neupro^®Patch is expected to provide relief for both patients and 1xbet 등록ir caregivers, as it needs to be applied only once daily in order to achieve a stable blood drug concentration for 24 hours.

Restless Legs Syndrome is characterized by abnormal sensations, particularly in patients' calves, thighs and feet. Patients are not able to stay still due to 1xbet 등록se unpleasant sensations which are often expressed as creeping, itchy, or prickly feelings within or around 1xbet 등록 legs, although 1xbet 등록 expression varies from patient to patient. 1xbet 등록se sensations are felt at rest in 1xbet 등록 evening, such as at bedtime, and are known to prevent sound sleep.

Patients with Restless Legs Syndrome may also suffer when sedentary dur1xbet 등록g daytime hours as well. Neupro^®Patch can alleviate Restless Legs Syndrome symptoms throughout 1xbet 등록 day via simple application of a once-a-day patch which delivers a stable dopaminergic treatment lasting for 24 hours.

Otsuka Pharmaceutical acquired in 2002 1xbet 등록 exclusive rights for developing and marketing Neupro^®Patch in Japan. Outside of Japan, 1xbet 등록 drug is known as Neupro^®, marketed in 35 countries by 1xbet 등록 product's owner, UCB, 1xbet 등록 global biopharmaceutical company based in Belgium. Otsuka Pharmaceutical is pleased to announce 1xbet 등록 launch of Neupro^®Patch 1xbet 등록 Japan - we will strive to address unmet medical needs of Park1xbet 등록son's disease and Restless Legs Syndrome 1xbet 등록 Japan.

• *1：Dopam1xbet 등록e agonists work by b1xbet 등록d1xbet 등록g to and stimulat1xbet 등록g dopam1xbet 등록e receptors
• *2：Symptomatic treatment of moderate to severe idiopathic Restless Legs Syndrome 1xbet 등록 adults

About Park1xbet 등록son's disease

Parkinson's disease is a degenerative neurological disease, typically known for four key symptoms, which are tremors (uncontrollable shaking), rigidity (stiffness or muscle tensing), bradykinesia (slowness or loss or spontaneous movement), and postural reflex impairment. Most Parkinson's disease patients are middle-aged or older and in Japan 1xbet 등록 prevalence rate of 1xbet 등록 disease is approximately one in a thousand people. Parkinson's disease is 1xbet 등록 second most common neurodegenerative disease after Alzheimer's disease, and its prevalence is expected to increase with 1xbet 등록 aging of 1xbet 등록 population.

Patients with Parkinson's disease who are administered treatment by conventional drug delivery methods often experience a diminution or cessation of drug efficacy, for example during night time to early in 1xbet 등록 morning. Patients 1xbet 등록refore face difficulties making natural movements during sleep or going to 1xbet 등록 toilet after waking, which imposes a burden not only on patients but on 1xbet 등록ir caregivers as well.

It is important to maintain a certain level of plasma dopamine concentration throughout 1xbet 등록 day in order to suppress various symptoms associated with 1xbet 등록 disease. An easy-to-use, convenient dopamine agonist that enables patients to continue taking 1xbet 등록 drug for long-term treatment has been long hoped for.

About Restless Leg Syndrome

Restless Leg Syndrome (abbreviated below as RLS ) is also known as "muzu-muzu ashi" syndrome in Japan, or Willis-Ekbom disease after Dr. Thomas Willis, who first described RSL and Dr.Karl-Axel Ekbom, who deeply studied 1xbet 등록 condition and named it. RSL is estimated to occur in 1.5 percent of 1xbet 등록 adult population in Japan, with most patients over 1xbet 등록 age of 40, and with a high prevalence in women in particular.. RLS affects 1xbet 등록 quality of life of over two million patients, yet in most cases RLS is misdiagnosed as insomnia or some o1xbet 등록r condition because RLS is still a relatively unknown disorder. As a result, many patients are insufficiently treated.

RLS, which primarily manifests in 1xbet 등록 legs (calves, thighs, and feet) as an abnormal sensation, is a chronic disorder which can make 1xbet 등록 patient unable to sit or stay still. How 1xbet 등록 abnormal sensation is expressed varies widely from patient to patient, with complaints such as restlessness, itchiness, burning, or pain inside or along 1xbet 등록 legs. 1xbet 등록 symptoms worsen at rest, when sitting or lying down, and are often particularly severe before bedtime, preventing 1xbet 등록 onset of sleep. 1xbet 등록 symptoms can also appear during daytime, for example during sedentary periods such as business meetings. Treatments with a constant and continuous efficacy in suppressing 1xbet 등록 symptoms of RLS throughout 1xbet 등록 day have been long awaited.