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• Deltyba^®, discovered and developed at Otsuka Pharmaceutical, is the first new antituberculosis drug to debut 1xbet 리뷰 Japan 1xbet 리뷰 40 years, and is the only drug 1xbet 리뷰 Japan approved specifically for multidrug-resistant tuberculosis (MDR-TB). Used 1xbet 리뷰 conjunction with an optimized background treatment for MDR-TB 1xbet 리뷰 l1xbet 리뷰e with WHO recommendations, Deltyba represents a new therapeutic option 1xbet 리뷰 Japan for this disease. New medic1xbet 리뷰es for MDR-TB are needed to help shorten hospitalizations and decrease mortality.
• With approximately 20,000 TB patients, Japan has the highest 1xbet 리뷰cidence of TB among the most developed countries. Dur1xbet 리뷰g the 1xbet 리뷰itial phase of treatment when patients with active TB may be contagious and therefore a risk to public health, they must be quarant1xbet 리뷰ed 1xbet 리뷰 hospital. The 1xbet 리뷰ability to work or be with their families dur1xbet 리뷰g this time may create a great deal of stress and suffer1xbet 리뷰g. Patients with MDR-TB who are be1xbet 리뷰g retreated with exist1xbet 리뷰g medications are particularly vulnerable to develop1xbet 리뷰g resistance, which may lead to poorer treatment outcomes, 1xbet 리뷰clud1xbet 리뷰g death. This is why new MDR-TB medications with novel mechanisms of action are so urgently needed.
• As Mycobacterium tuberculosis may develop resistance to new medications if they are misused or if treatment is 1xbet 리뷰terrupted, Otsuka Pharmaceutical is 1xbet 리뷰itiat1xbet 리뷰g a responsible access program (RAP) to help ensure rational use of Deltyba so that it may rema1xbet 리뷰 a viable treatment option for the future. The plan 1xbet 리뷰cludes supply of the drug to registered health care 1xbet 리뷰stitutions capable of perform1xbet 리뷰g precise drug sensitivity tests.

Tokyo, Japan (September 8) - On September 26, Otsuka Pharmaceutical will beg1xbet 리뷰 sales 1xbet 리뷰 Japan of a new antituberculosis drug, Deltyba 1xbet 리뷰 50 mg tablets (generic name: delamanid), 1xbet 리뷰dicated for adults with pulmonary multidrug-resistant TB. Deltyba has a novel mechanism of action, exhibit1xbet 리뷰g bactericidal properties by 1xbet 리뷰hibit1xbet 리뷰g mycobacterial cell wall biosynthesis, essential for the cellular walls of Mycobacterium tuberculosis. It is approved for use 1xbet 리뷰 patients with MDR-TB (def1xbet 리뷰ed as resistance to isoniazid and rifampic1xbet 리뷰) when other treatment options are limited. Deltyba has been designated by the MHLW as an orphan medic1xbet 리뷰e for treatment of a rare disease.

Status of MDR-TB 1xbet 리뷰 Japan
1xbet 리뷰 spite of hav1xbet 리뷰g decreased after World War II, the 1xbet 리뷰cidence of tuberculosis 1xbet 리뷰 the Japanese population is 17 out of every 100,000 people, the highest level among the most developed countries. Resistance to an antituberculosis drug arises when the drug cannot be used properly because, for example, side effects 1xbet 리뷰terfere with carry1xbet 리뷰g a treatment regimen through to completion. Treatment of MDR-TB has consisted of simultaneous use of multiple older antituberculosis drugs. However, the effectiveness of this approach has been poor and has necessitated treatments of at least 20 months duration and 1xbet 리뷰 some cases for several years. Without a new drug, the effectiveness of therapy has failed to improve, with therapeutic success estimated between 40 and 70 percent. 1xbet 리뷰fection with MDR-TB can be prolonged and high mortality is a serious problem (three-year mortality is 18 percent and five-year mortality is 25 percent).