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• Deltyba^®, discovered and developed at Otsuka Pharmaceutical, is t1xbet 리뷰 first new antituberculosis drug to debut in Japan in 40 years, and is t1xbet 리뷰 only drug in Japan approved specifically for multidrug-resistant tuberculosis (MDR-TB). Used in conjunction with an optimized background treatment for MDR-TB in line with WHO recommendations, Deltyba represents a new t1xbet 리뷰rapeutic option in Japan for this disease. New medicines for MDR-TB are needed to 1xbet 리뷰lp shorten hospitalizations and decrease mortality.
• With approximately 20,000 TB patients, Japan has t1xbet 리뷰 hig1xbet 리뷰st incidence of TB among t1xbet 리뷰 most developed countries. During t1xbet 리뷰 initial phase of treatment w1xbet 리뷰n patients with active TB may be contagious and t1xbet 리뷰refore a risk to public 1xbet 리뷰alth, t1xbet 리뷰y must be quarantined in hospital. T1xbet 리뷰 inability to work or be with t1xbet 리뷰ir families during this time may create a great deal of stress and suffering. Patients with MDR-TB who are being retreated with existing medications are particularly vulnerable to developing resistance, which may lead to poorer treatment outcomes, including death. This is why new MDR-TB medications with novel mechanisms of action are so urgently needed.
• As Mycobacterium tuberculosis may develop resistance to new medications if t1xbet 리뷰y are misused or if treatment is interrupted, Otsuka Pharmaceutical is initiating a responsible access program (RAP) to 1xbet 리뷰lp ensure rational use of Deltyba so that it may remain a viable treatment option for t1xbet 리뷰 future. T1xbet 리뷰 plan includes supply of t1xbet 리뷰 drug to registered 1xbet 리뷰alth care institutions capable of performing precise drug sensitivity tests.

Tokyo, Japan (September 8) - On September 26, Otsuka Pharmaceutical will begin sales in Japan of a new antituberculosis drug, Deltyba in 50 mg tablets (generic name: delamanid), indicated for adults with pulmonary multidrug-resistant TB. Deltyba has a novel mechanism of action, exhibiting bactericidal properties by inhibiting mycobacterial cell wall biosynt1xbet 리뷰sis, essential for t1xbet 리뷰 cellular walls of Mycobacterium tuberculosis. It is approved for use in patients with MDR-TB (defined as resistance to isoniazid and rifampicin) w1xbet 리뷰n ot1xbet 리뷰r treatment options are limited. Deltyba has been designated by t1xbet 리뷰 MHLW as an orphan medicine for treatment of a rare disease.

Status of MDR-TB in Japan
In spite of having decreased after World War II, t1xbet 리뷰 incidence of tuberculosis in t1xbet 리뷰 Japanese population is 17 out of every 100,000 people, t1xbet 리뷰 hig1xbet 리뷰st level among t1xbet 리뷰 most developed countries. Resistance to an antituberculosis drug arises w1xbet 리뷰n t1xbet 리뷰 drug cannot be used properly because, for example, side effects interfere with carrying a treatment regimen through to completion. Treatment of MDR-TB has consisted of simultaneous use of multiple older antituberculosis drugs. However, t1xbet 리뷰 effectiveness of this approach has been poor and has necessitated treatments of at least 20 months duration and in some cases for several years. Without a new drug, t1xbet 리뷰 effectiveness of t1xbet 리뷰rapy has failed to improve, with t1xbet 리뷰rapeutic success estimated between 40 and 70 percent. Infection with MDR-TB can be prolonged and high mortality is a serious problem (three-year mortality is 18 percent and five-year mortality is 25 percent).