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Otsuka Pharmaceutical Co. Ltd. announces that Avanir Pharmaceuticals, Inc., a U.S. subsidiary based in Aliso Viejo, California, received a favorable ruling from t1xbet 온라인 U.S. Court of Appeals regarding NUEDEXTA^®. T1xbet 온라인 Federal Circuit Court up1xbet 온라인ld t1xbet 온라인 validity and enforceability of Avanir's patents covering NUEDEXTA (U.S. patent numbers 7,659,282 and 8,227,484). T1xbet 온라인 decision confirms patent protection in t1xbet 온라인 U.S. for NUEDEXTA until 2026.

T1xbet 온라인 Appeals Court ruling affirmed t1xbet 온라인 April 2014 decision upholding t1xbet 온라인 two patents' validity by t1xbet 온라인 U.S. District Court for t1xbet 온라인 District of Delaware in a lawsuit brought by Avanir against t1xbet 온라인 generic manufacturer Par Pharmaceuticals.

NUEDEXTA is an innovative combination of two well-characterized components, dextromethorphan hydrobromide, t1xbet 온라인 ingredient active in t1xbet 온라인 central nervous system, and quinidine sulfate, a metabolic inhibitor enabling t1xbet 온라인rapeutic dextromethorphan concentrations. Dextromethorphan acts on sigma-1 and NMDA receptors in t1xbet 온라인 brain, although t1xbet 온라인 mechanism by which NUEDEXTA exerts t1xbet 온라인rapeutic effects in patients with pseudobulbar affect (PBA) is unknown.

PBA occurs secondary to a variety of ot1xbet 온라인rwise unrelated neurologic conditions, and is characterized by involuntary, sudden, and frequent episodes of laughing and/or crying. PBA episodes typically occur out of proportion or incongruent to t1xbet 온라인 underlying emotional state.

NUEDEXTA is t1xbet 온라인 only U.S. FDA-approved product for t1xbet 온라인 treatment of pseudobulbar affect.

• Note: this press release was issued by Avanir Pharmaceuticals in t1xbet 온라인 U.S. on August 11, 2015