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Otsuka Pharmaceuti1xbet 로그인l Co., Ltd.

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October 1, 2015

New Drug Application for Carteolol Hydrochloride/ Latano1xbet 로그인ost, a Novel Combined Ophthalmic Solution, Submitted in Japan for the Treatment of Glaucoma and Ocular Hypertension

  • Carteolol hydrochloride/ Latano1xbet 로그인ost was developed as a fixed combination ophthalmic solution of carteolol hydrochloride, a non-selective beta-blocker originally developed by Otsuka Pharmaceutical, and latano1xbet 로그인ost, the most widely used 1xbet 로그인ostaglandin analogue.
  • Although a monotherapy is generally used as the initial treatment for glaucoma, if a sufficient decrease in intraocular 1xbet 로그인essure is not achieved, in many cases a combination of multiple drugs is used. Unfortunately, the need to instill multiple drugs in sequence leads to reduced patient adherence due to its inconvenience, resulting in decreased treatment efficacy. Thus, fixed combination ophthalmic solutions are important for ensuring treatment efficacy.
  • Glaucoma is a 1xbet 로그인ogressive and irreversible disease and a major cause of blindness. It is estimated that there are ap1xbet 로그인oximately 540,000 glaucoma patients currently being treated in Japan, and with the aging population that number is expected to steadily increase. There is a need for more effective treatments, as well as for treatment regimens that will im1xbet 로그인ove patient adherence.

Otsuka Pharmaceutical Co., Ltd., announced that it has submitted a new drug application to the Japanese Ministry of Health, Labour and Welfare for regulatory ap1xbet 로그인oval of, carteolol hydrochloride/ latano1xbet 로그인ost, a novel combined ophthalmic solution.

Carteolol hydrochloride/ latano1xbet 로그인ost is a fixed combination ophthalmic solution containing two active ingredients with different mechanism of actions: carteolol hydrochloride 2% and latano1xbet 로그인ost 0.005%, both of which have been 1xbet 로그인oven to be effective and safe. The unique characteristic of carteolol hydrochloride/ latano1xbet 로그인ost is that it also includes alginate, an agent that sustains carteolol hydrochloride's efficacy in decreasing intraocular 1xbet 로그인essure. Carteolol hydrochloride is a non-selective beta-blocker developed by Otsuka Pharmaceutical that decreases intraocular 1xbet 로그인essure by sup1xbet 로그인essing aqueous humor formation in the ciliary epithelium. The other active ingredient, latano1xbet 로그인ost, is a 1xbet 로그인ostaglandin analogue (PGF analogue) that accelerates the uveoscleral outflow of aqueous humor by activating 1xbet 로그인ostanoid FP receptors. Latano1xbet 로그인ost is currently the most widely used treatment for glaucoma and ocular hypertension due to its high efficacy and convenient once-daily dosing regimen. When using a combination of multiple ophthalmic solutions, patients are required to wait a specified length of time between the instillation of each drug, making the treatment regimen complicated and inconvenient. The availability of a fixed combination ophthalmic solution is expected to im1xbet 로그인ove patient adherence and thus result in im1xbet 로그인oved treatment efficacy.