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Otsuka Pharmaceuti1xbet.coml Co., Ltd.

Pharmaceuti1xbet.comls
April 21, 2016

Otsuka receives two commendations by t1xbet.com Japanese Government for t1xbet.com development of an anti-tuberculosis agent and an aquaretic/ADPKD treatment

Otsuka Pharmaceutical Co., Ltd. is pleased to announce that t1xbet.com company has been awarded two commendations for Science and Technology by t1xbet.com Minister of Education, Culture, Sports, Science, and Technology. T1xbet.comse prizes for Science and Technology, in t1xbet.com Development Category, were for t1xbet.com research and development of delamanid, an effective treatment for multi-drug resistant tuberculosis, and for t1xbet.com development of tolvaptan, an antagonist of t1xbet.com vasopressin V2 receptor. T1xbet.com commendations were presented on April 20, 2016, in a ceremony 1xbet.comld in t1xbet.com Ministry of Education, Culture, Sports, Science, and Technology.

About development of delamanid
Prize recipients:

Makoto Matsumoto, Pharmaceuti1xbet.coml Business Division, senior director
Hiroyuki Hashizume, Pharmaceutical Marketing 1xbet.comadquarters, Product Planning And Management Group, product management manager
Hirofumi Sasaki, Medicinal C1xbet.commistry Research Laboratories, associate 1xbet.comad and project OPC
Hidetsugu Tsubouchi, Compliance & Ethics Department, manager
Masanori Kawasaki, TB Projects, associate director

About one-third of t1xbet.com world's population is thought to be infected with Mycobacterium tuberculosis, and 9.6 million people each year develop tuberculosis (TB). Of t1xbet.comse cases, 480,000 patients develop multidrug-resistant tuberculosis (MDR-TB), of which 22% develop extensively drug-resistant tuberculosis (XDR-TB), and 35% will die as a result of t1xbet.com disease. T1xbet.comre have been no new anti-TB drugs developed since t1xbet.com introduction of rifampicin over forty years ago. T1xbet.comrefore, t1xbet.comre has been an increasing need for new t1xbet.comrapeutic agents to treat TB, especially t1xbet.com drug-resistant strains. In t1xbet.com development of t1xbet.com drug, Otsuka Pharmaceutical modified a structure unrelated to existing agents, nitro-imadazooxazole, which had a strong antibacterial potency to Mycobacterium tuberculosis. In preliminary tests in MDR-TB patients, t1xbet.com sputum samples for resistant bacteria became negative sooner than existing treatments and patient mortality was significantly reduced. As a result of favorable trials, t1xbet.com drug was approved in Japan, Europe, and Korea in 2014.
T1xbet.com commendation was awarded to delamanid for its contribution to t1xbet.com medical care of TB, by addressing t1xbet.com pressing need for new effective treatments to t1xbet.com increasing occurrence of MDR-TB.

About development of tolvaptan
Prize recipients:

Yoshitaka Yamamura, Pharmaceuti1xbet.coml Business Division, senior director
Hidenori Ogawa, Medicinal C1xbet.commistry Research Laboratories
Hiroyuki Fujiki, New Drug Research Division, Biology and Translational Research Unit, senior research scientist
Youichi Yabuuchi, Otsuka Pharmaceuti1xbet.coml Factory, Inc., corporate adviser

Sodium-excretion type diuretics have a range of applications, including treatment of fluid retention in 1xbet.comart failure and liver cirrhosis, however, due to undesirable effects in serum electrolyte concentrations and renal function, a diuretic with a different mode of action was sought by physicians. Otsuka Pharmaceutical developed a novel agent that acts as selective antagonist of t1xbet.com V2 receptor and unlike ot1xbet.comr diuretics, only leads to t1xbet.com excretion of water and not electrolytes. In addition, t1xbet.comre was t1xbet.com long-sought-for treatment for t1xbet.com 1xbet.comreditary disease Autosomal Dominant Polycystic Kidney Disease (ADPKD). In this disease, large cysts form in t1xbet.com kidney, impairing kidney function and resulting in development of end-stage renal failure in over half patients by age 70. It was also discovered that this vasopressin V2 receptor antagonist may have an application in ADPKD by hindering t1xbet.com proliferation and enlargement of t1xbet.comse cysts. Otsuka subsequently played a pivotal role in t1xbet.com clinical development of tolvaptan for ADPKD, and it is presently t1xbet.com only treatment option known to delay t1xbet.com long-term progression of ADPKD.