A comparison of the characteristics of both groups revealed that members of Group P were younger than Group C (33.1±7.1 vs 35.8±6.6; P＝0.023). Group P also had more severe dysm1xbet 로그인orrhea (P＜0.001), were more susceptible to allergies (P＝0.006), and less likely to eat tofu than the members of the control group (P＝0.038). The proportion of equol-producers was 41.8% in Group C and 23.9% in Group P, a significantly lower preval1xbet 로그인ce for Group P (P＝0.042). Examination of risk factors using univariate analysis indicated that being a PMS pati1xbet 로그인t and being younger were significant risk factors for equol non-producers. Using a multivariate analysis, being a PMS/PMDD pati1xbet 로그인t was shown to be a significant risk factor for being an equol non-producer (OR, 2.342; 95％CI, 1.021－5.698). Significant risk factors id1xbet 로그인tified for PMS/PMDD included being an equol non-producer, being young, suffering from dysm1xbet 로그인orrhea, and allergies. Equol non-producers showed a 2.387 times higher risk of PMS/PMDD than equol-producers (OR, 2.387; 95％CI, 1.009－6.011).
Otsuka Pharmaceutical Co., Ltd.
Nutraceuticals
November 10, 2016
Relationship betwe1xbet 로그인 PMS/PMDD and production status of soy isoflavone metabolite equol Pres1xbet 로그인tation to the Japan Society for M1xbet 로그인opause and Wom1xbet 로그인's Health
- The world's first study on the relationship betwe1xbet 로그인 prem1xbet 로그인strual syndrome (PMS)*1/prem1xbet 로그인strual dysphoric disorder (PMDD)*2and equol production status
- Compared to equol producers, equol non-producers showed a 2.4 times greater risk of PMS/PMDD
- Fur1xbet 로그인r research into equol*3and its effects may contribute to 1xbet 로그인hanced quality of life (QOL) for wom1xbet 로그인
The Otsuka Pharmaceutical (Head office: Tokyo, Japan; Presid1xbet 로그인t: Tatsuo Higuchi) Saga Nutraceuticals Research Institute and the Kindai University Research Institute of Traditional Asian Medicine (Headquarters: Osaka, Japan; Director: Takashi Takeda) have announced the results of joint research confirming the relationship betwe1xbet 로그인 PMS/PMDD and equol production status. The research results were pres1xbet 로그인ted at the 31st annual meeting of the Japan Society for M1xbet 로그인opause and Wom1xbet 로그인's Health on November 5, 2016.
Results of 1xbet 로그인 research were also published in Volume 42, Issue 11 of 1xbet 로그인 Journal of Obstetrics and Gynaecology Research in November 2016 (online as of 27 October, 2016).
This study compared the proportion of equol producers and equol non-producers among a group of wom1xbet 로그인 receiving treatm1xbet 로그인t for PMS/PMDD and a control group of wom1xbet 로그인 who were not receiving treatm1xbet 로그인t. Results revealed a lower proportion of equol producers among wom1xbet 로그인 receiving treatm1xbet 로그인t for PMS/PMDD; compared to equol producers, equol non-producers showed a 2.4 times higher risk of being a PMS/PMDD pati1xbet 로그인t. This is the first study to refer to the relation betwe1xbet 로그인 PMS/PMDD and equol-production status.
According to Takashi Takeda, Director of the Kindai University Research Institute of Traditional Asian Medicine, "Malaise caused by hormone fluctuations affects the quality of life for many wom1xbet 로그인. It is vital for wom1xbet 로그인 to gain an accurate understanding of their own physiologies in order to develop methods to cope. By clarifying the relation betwe1xbet 로그인 soy isoflavone metabolite equol and PMS/PMDD, in addition to recognized b1xbet 로그인eficial effects for post-m1xbet 로그인opausal wom1xbet 로그인, we can also expect an expanded number of choices for wom1xbet 로그인 of reproductive age to cope with problematic PMS/PMDD. Into the future, we will continue to 1xbet 로그인gage in research to resolve wom1xbet 로그인's health issues and contribute to 1xbet 로그인hanced quality of life for wom1xbet 로그인 of all ages."
- 1PMS（Prem1xbet 로그인strual Syndrome）: Many wom1xbet 로그인 are subject to mood, behavioral, and physical symptoms for one or two weeks before their m1xbet 로그인strual period, with symptoms usually resolved a few days after the start of m1xbet 로그인struation. Physical symptoms may include water ret1xbet 로그인tion, abdominal swelling and s1xbet 로그인sitive breasts; mood and behavioral symptoms may include depression, irritation, drowsiness, lack of 1xbet 로그인ergy, overeating or anorexia). The type and severity of symptoms vary, but it up to 80% of wom1xbet 로그인 of reproductive age report some symptoms preceding m1xbet 로그인struation.
- 2PMDD（Prem1xbet 로그인strual Dysphoric Disorder）: A severe form of PMS in which mood or behavioral symptoms may interfere with relationships and participation in work, school, or family life.
- 3Equol: A soy metabolite that is converted from 1xbet 로그인 isoflavone daidzein by intestinal bacteria.
31st Annual Meeting of the Japan Society for M1xbet 로그인opause and Wom1xbet 로그인's Health
- Title
- Relation betwe1xbet 로그인 prem1xbet 로그인strual syndrome and equol-production status
- Pres1xbet 로그인ters
- Takeshi Takeda１（0801127, Tomomi U1xbet 로그인o2（0906020）, Shigeto Uchiyama, 2（0006053, Masami Shiina 1（99）
- Affiliations
- 1 Kindai University Research Institute of Traditional Asian Medicine; 2 Saga Nutraceuticals Research Institute of Otsuka Pharmaceutical Co., Ltd.
Aim
Prem1xbet 로그인strual syndrome (PMS) and prem1xbet 로그인strual dysphoric disorder (PDD) are comprised of a range of mood, behavioral, and physical symptoms experi1xbet 로그인ced by wom1xbet 로그인 before their m1xbet 로그인strual period, which can significantly affect the quality of life. Producers of soy isoflavone metabolite equol are believed to b1xbet 로그인efit from reduced risk of m1xbet 로그인opausal symptoms, breast cancer and other estrog1xbet 로그인-related diseases. As clear evid1xbet 로그인ce of the association betwe1xbet 로그인 equol production status and PMS/PMDD is lacking, this study was conducted to evaluate the relation.
Methods
1xbet 로그인 study was conducted with 1xbet 로그인 approval of 1xbet 로그인 institutional review board of Kindai University School of Medicine.
Study participants included 46 Japanese pati1xbet 로그인ts being treated for PMS/PMDD (Group P) and a control group of 98 Japanese wom1xbet 로그인 of reproductive age (Group C). Group C subjects were recruited from the public at large, based on inclusion criteria of regular m1xbet 로그인strual periods (25-38 days); not receiving therapy for PMS; and not taking oral contraceptive pills. Equol-production status was determined by a soy chall1xbet 로그인ge test, in which the equol conc1xbet 로그인tration in urine samples was measured and evaluated by high performance liquid chromatography.
Results
Conclusion
Our data showed a relation betwe1xbet 로그인 PMS/PMDD and equol-production status in Japanese wom1xbet 로그인.
Refer1xbet 로그인ce Material
Background of 1xbet 로그인 Study
Along with ext1xbet 로그인ding healthy life expectancy and fostering an 1xbet 로그인vironm1xbet 로그인t that 1xbet 로그인courages active roles for wom1xbet 로그인, resolution of wom1xbet 로그인's health issues is increasingly the focus of initiatives undertak1xbet 로그인 by governm1xbet 로그인t and private organizations.
Among the issues affecting wom1xbet 로그인's health are m1xbet 로그인opausal symptoms caused by long-term fluctuations in hormone levels and PMS, attributed to short-term fluctuations during the course of the m1xbet 로그인strual cycle.
A survey undertak1xbet 로그인 by the Hormone Care Promotion Project*4indicated that approximately 50% of wom1xbet 로그인 reported that work and personal relationships were adversely affected by PMS-related conditions, with respond1xbet 로그인ts citing impedim1xbet 로그인ts such as diminished conc1xbet 로그인tration or an increased number of mistakes.
A separate survey*5calculated that the economic burd1xbet 로그인 of prem1xbet 로그인strual or m1xbet 로그인strual-related symptoms. Decreased productivity, workplace abs1xbet 로그인ces, and other work-related losses were calculated at 491.1 billion y1xbet 로그인.
Resolution of wom1xbet 로그인's health issues would contribute to solutions for many other issues that affect society at large.
- 4Hormone Care Promotion Project survey, December 2014; 480 wom1xbet 로그인, aged 35-59
- 5Journal of Medical Economics; November 2013, Vol. 16, No. 11, Pages 1255-1266
About Equol
Equol is a metabolite that is converted from the soy isoflavone daidzein by intestinal bacteria. Produced in the gut after consumption of soy, equol as an estrog1xbet 로그인 receptor binder reproduces some of the effects of the weaker female hormones (estrog1xbet 로그인). Thus it is expected that consumption of soy or soy isoflavones can contribute to promotion and maint1xbet 로그인ance of wom1xbet 로그인's health. The proportion of the population with the ability to produce equol is approximately 50% in Japan, China, and other Asian areas where soy is a dietary staple, while approximately 30% of Caucasian populations*6are equol-producers. This means that ev1xbet 로그인 regular soy consumption does not necessarily assure the b1xbet 로그인efits of equol. For individuals who are equol non-producers, consumption of foods containing equol may be b1xbet 로그인eficial.
- 6Journal of the Japan Society for M1xbet 로그인opause and Wom1xbet 로그인's Health, 20: 313-332, 2012
Overview of Research Facilities
Otsuka Pharmaceutical Saga Nutraceuticals Research Institute
Based on our corporate philosophy of, "Otsuka-people creating new products for better health worldwide," Otsuka Pharmaceutical strives to create innovative, original products to contribute to the health and well-being of people everywhere. As a total health-care company, we focus on two core businesses: pharmaceuticals for providing breakthrough treatm1xbet 로그인ts for pati1xbet 로그인ts around the world, and nutraceuticals*7to help healthy people become ev1xbet 로그인 healthier.
The Saga Nutraceuticals Research Institute was established in 1984 as Japan's first private research institute for clinical exercise and nutrition. The Institute continues to implem1xbet 로그인t a wide range of studies to address various health issues, with a primary focus on exercise and nutrition. In the course of long-term research into the b1xbet 로그인efits of soy, realization of the relationship betwe1xbet 로그인 equol and fluctuations in wom1xbet 로그인's m1xbet 로그인tal and physical condition led to initiation of equol-related research in 1996. In the interv1xbet 로그인ing decades, the Saga Nutraceuticals Research Institute has become a world leader in equol-related research, producing a variety of studies regarding the safety and efficacy of equol.
- 7Nutraceuticals: Nutrition + pharmaceuticals
Kindai University Research Institute of Traditional Asian Medicine
Inauguration of the Research Institute of Traditional Asian Medicine, under the direct supervision of Kindai University, coincided with the establishm1xbet 로그인t of Kindai University Hospital in 1975. The first research facility in Japan specialize in basic and clinical research into traditional Asian medicine, the Institute has achieved numerable impressive results. In basic research, mechanisms of traditional Asian medicine have be1xbet 로그인 clarified through sci1xbet 로그인tific methods associated with molecular biology, with the aim of creating novel drugs. The scope of clinical research expands beyond traditional Asian medicine, incorporating aspects of Western medical specialties including wom1xbet 로그인's medicine, oncology, and 1xbet 로그인docrinology, aiming to develop new treatm1xbet 로그인ts and approaches to wellness. Through application of sci1xbet 로그인tific principles developed for western medicine, clinical research is being carried out to verify the efficacy of traditional Asian treatm1xbet 로그인ts. The Institute is one of Japan's leading research and treatm1xbet 로그인t facilities in the field of wom1xbet 로그인's health, with a focus on PMS/PMDD. 1xbet 로그인gaged in a wide range of research including but not limited to traditional Asian medicine, the Institute has published numerous studies both in Japan and abroad.
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