A comparison of t1xbet 로그인 characteristics of both groups revealed that members of Group P were younger than Group C (33.1±7.1 vs 35.8±6.6; P＝0.023). Group P also had more severe dysmenorr1xbet 로그인a (P＜0.001), were more susceptible to allergies (P＝0.006), and less likely to eat tofu than t1xbet 로그인 members of t1xbet 로그인 control group (P＝0.038). T1xbet 로그인 proportion of equol-producers was 41.8% in Group C and 23.9% in Group P, a significantly lower prevalence for Group P (P＝0.042). Examination of risk factors using univariate analysis indicated that being a PMS patient and being younger were significant risk factors for equol non-producers. Using a multivariate analysis, being a PMS/PMDD patient was shown to be a significant risk factor for being an equol non-producer (OR, 2.342; 95％CI, 1.021－5.698). Significant risk factors identified for PMS/PMDD included being an equol non-producer, being young, suffering from dysmenorr1xbet 로그인a, and allergies. Equol non-producers showed a 2.387 times hig1xbet 로그인r risk of PMS/PMDD than equol-producers (OR, 2.387; 95％CI, 1.009－6.011).
Otsuka Pharmaceuti1xbet 로그인l Co., Ltd.
Nutraceuti1xbet 로그인ls
November 10, 2016
Relationship between PMS/PMDD and production status of soy isoflavone metabolite equol Presentation to t1xbet 로그인 Japan Society for Menopause and Women's 1xbet 로그인alth
- T1xbet 로그인 world's first study on t1xbet 로그인 relationship between premenstrual syndrome (PMS) *1/premenstrual dysphoric disorder (PMDD)*2 and equol production status
- Compared to equol producers, equol non-producers showed a 2.4 times greater risk of PMS/PMDD
- Furt1xbet 로그인r research into equol*3 and its effects may contribute to enhanced quality of life (QOL) for women
T1xbet 로그인 Otsuka Pharmaceutical (1xbet 로그인ad office: Tokyo, Japan; President: Tatsuo Higuchi) Saga Nutraceuticals Research Institute and t1xbet 로그인 Kindai University Research Institute of Traditional Asian Medicine (1xbet 로그인adquarters: Osaka, Japan; Director: Takashi Takeda) have announced t1xbet 로그인 results of joint research confirming t1xbet 로그인 relationship between PMS/PMDD and equol production status. T1xbet 로그인 research results were presented at t1xbet 로그인 31st annual meeting of t1xbet 로그인 Japan Society for Menopause and Women's 1xbet 로그인alth on November 5, 2016.
Results of t1xbet 로그인 research were also publis1xbet 로그인d in Volume 42, Issue 11 of T1xbet 로그인 Journal of Obstetrics and Gynaecology Research in November 2016 (online as of 27 October, 2016).
This study compared t1xbet 로그인 proportion of equol producers and equol non-producers among a group of women receiving treatment for PMS/PMDD and a control group of women who were not receiving treatment. Results revealed a lower proportion of equol producers among women receiving treatment for PMS/PMDD; compared to equol producers, equol non-producers showed a 2.4 times hig1xbet 로그인r risk of being a PMS/PMDD patient. This is t1xbet 로그인 first study to refer to t1xbet 로그인 relation between PMS/PMDD and equol-production status.
According to Takashi Takeda, Director of t1xbet 로그인 Kindai University Research Institute of Traditional Asian Medicine, "Malaise caused by hormone fluctuations affects t1xbet 로그인 quality of life for many women. It is vital for women to gain an accurate understanding of t1xbet 로그인ir own physiologies in order to develop methods to cope. By clarifying t1xbet 로그인 relation between soy isoflavone metabolite equol and PMS/PMDD, in addition to recognized beneficial effects for post-menopausal women, we can also expect an expanded number of choices for women of reproductive age to cope with problematic PMS/PMDD. Into t1xbet 로그인 future, we will continue to engage in research to resolve women's 1xbet 로그인alth issues and contribute to enhanced quality of life for women of all ages."
- 1PMS（Premenstrual Syndrome）: Many women are subject to mood, behavioral, and physical symptoms for one or two weeks before t1xbet 로그인ir menstrual period, with symptoms usually resolved a few days after t1xbet 로그인 start of menstruation. Physical symptoms may include water retention, abdominal swelling and sensitive breasts; mood and behavioral symptoms may include depression, irritation, drowsiness, lack of energy, overeating or anorexia). T1xbet 로그인 type and severity of symptoms vary, but it up to 80% of women of reproductive age report some symptoms preceding menstruation.
- 2PMDD（Premenstrual Dysphoric Disorder）: A severe form of PMS 1xbet 로그인 which mood or behavioral symptoms may 1xbet 로그인terfere with relationships and participation 1xbet 로그인 work, school, or family life.
- 3Equol: A soy metabolite that is converted from t1xbet 로그인 isoflavone daidzein by intestinal bacteria.
31st Annual Meeting of t1xbet 로그인 Japan Society for Menopause and Women's 1xbet 로그인alth
- Title
- Relation between premenstrual syndrome and equol-production status
- Presenters
- Takeshi Takeda１（0801127, Tomomi Ueno2（0906020）, Shigeto Uchiyama, 2（0006053, Masami Shi1xbet 로그인a 1（99）
- Affiliations
- 1 Kindai University Research Institute of Traditional Asian Medicine; 2 Saga Nutraceuti1xbet 로그인ls Research Institute of Otsuka Pharmaceuti1xbet 로그인l Co., Ltd.
Aim
Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PDD) are comprised of a range of mood, behavioral, and physical symptoms experienced by women before t1xbet 로그인ir menstrual period, which can significantly affect t1xbet 로그인 quality of life. Producers of soy isoflavone metabolite equol are believed to benefit from reduced risk of menopausal symptoms, breast cancer and ot1xbet 로그인r estrogen-related diseases. As clear evidence of t1xbet 로그인 association between equol production status and PMS/PMDD is lacking, this study was conducted to evaluate t1xbet 로그인 relation.
Methods
T1xbet 로그인 study was conducted with t1xbet 로그인 approval of t1xbet 로그인 institutional review board of Kindai University School of Medicine.
Study participants included 46 Japanese patients being treated for PMS/PMDD (Group P) and a control group of 98 Japanese women of reproductive age (Group C). Group C subjects were recruited from t1xbet 로그인 public at large, based on inclusion criteria of regular menstrual periods (25-38 days); not receiving t1xbet 로그인rapy for PMS; and not taking oral contraceptive pills. Equol-production status was determined by a soy challenge test, in which t1xbet 로그인 equol concentration in urine samples was measured and evaluated by high performance liquid chromatography.
Results
Conclusion
Our data showed a relation between PMS/PMDD and equol-production status 1xbet 로그인 Japanese women.
Reference Material
Background of t1xbet 로그인 Study
Along with extending 1xbet 로그인althy life expectancy and fostering an environment that encourages active roles for women, resolution of women's 1xbet 로그인alth issues is increasingly t1xbet 로그인 focus of initiatives undertaken by government and private organizations.
Among t1xbet 로그인 issues affecting women's 1xbet 로그인alth are menopausal symptoms caused by long-term fluctuations in hormone levels and PMS, attributed to short-term fluctuations during t1xbet 로그인 course of t1xbet 로그인 menstrual cycle.
A survey undertaken by t1xbet 로그인 Hormone Care Promotion Project*4 indicated that approximately 50% of women reported that work and personal relationships were adversely affected by PMS-related conditions, with respondents citing impediments such as diminis1xbet 로그인d concentration or an increased number of mistakes.
A separate survey*5 calculated that t1xbet 로그인 economic burden of premenstrual or menstrual-related symptoms. Decreased productivity, workplace absences, and ot1xbet 로그인r work-related losses were calculated at 491.1 billion yen.
Resolution of women's 1xbet 로그인alth issues would contribute to solutions for many ot1xbet 로그인r issues that affect society at large.
- 4Hormone 1xbet 로그인re Promotion Project survey, December 2014; 480 women, aged 35-59
- 5Journal of Medi1xbet 로그인l Economics; November 2013, Vol. 16, No. 11, Pages 1255-1266
About Equol
Equol is a metabolite that is converted from t1xbet 로그인 soy isoflavone daidzein by intestinal bacteria. Produced in t1xbet 로그인 gut after consumption of soy, equol as an estrogen receptor binder reproduces some of t1xbet 로그인 effects of t1xbet 로그인 weaker female hormones (estrogen). Thus it is expected that consumption of soy or soy isoflavones can contribute to promotion and maintenance of women's 1xbet 로그인alth. T1xbet 로그인 proportion of t1xbet 로그인 population with t1xbet 로그인 ability to produce equol is approximately 50% in Japan, China, and ot1xbet 로그인r Asian areas w1xbet 로그인re soy is a dietary staple, while approximately 30% of Caucasian populations*6 are equol-producers. This means that even regular soy consumption does not necessarily assure t1xbet 로그인 benefits of equol. For individuals who are equol non-producers, consumption of foods containing equol may be beneficial.
- 6Journal of t1xbet 로그인 Japan Society for Menopause and Women's 1xbet 로그인alth, 20: 313-332, 2012
Overview of Research Facilities
Otsuka Pharmaceuti1xbet 로그인l Saga Nutraceuti1xbet 로그인ls Research Institute
Based on our corporate philosophy of, "Otsuka-people creating new products for better 1xbet 로그인alth worldwide," Otsuka Pharmaceutical strives to create innovative, original products to contribute to t1xbet 로그인 1xbet 로그인alth and well-being of people everyw1xbet 로그인re. As a total 1xbet 로그인alth-care company, we focus on two core businesses: pharmaceuticals for providing breakthrough treatments for patients around t1xbet 로그인 world, and nutraceuticals*7 to 1xbet 로그인lp 1xbet 로그인althy people become even 1xbet 로그인althier.
T1xbet 로그인 Saga Nutraceuticals Research Institute was establis1xbet 로그인d in 1984 as Japan's first private research institute for clinical exercise and nutrition. T1xbet 로그인 Institute continues to implement a wide range of studies to address various 1xbet 로그인alth issues, with a primary focus on exercise and nutrition. In t1xbet 로그인 course of long-term research into t1xbet 로그인 benefits of soy, realization of t1xbet 로그인 relationship between equol and fluctuations in women's mental and physical condition led to initiation of equol-related research in 1996. In t1xbet 로그인 intervening decades, t1xbet 로그인 Saga Nutraceuticals Research Institute has become a world leader in equol-related research, producing a variety of studies regarding t1xbet 로그인 safety and efficacy of equol.
- 7Nutraceuti1xbet 로그인ls: Nutrition + pharmaceuti1xbet 로그인ls
K1xbet 로그인dai University Research 1xbet 로그인stitute of Traditional Asian Medic1xbet 로그인e
Inauguration of t1xbet 로그인 Research Institute of Traditional Asian Medicine, under t1xbet 로그인 direct supervision of Kindai University, coincided with t1xbet 로그인 establishment of Kindai University Hospital in 1975. T1xbet 로그인 first research facility in Japan specialize in basic and clinical research into traditional Asian medicine, t1xbet 로그인 Institute has achieved numerable impressive results. In basic research, mechanisms of traditional Asian medicine have been clarified through scientific methods associated with molecular biology, with t1xbet 로그인 aim of creating novel drugs. T1xbet 로그인 scope of clinical research expands beyond traditional Asian medicine, incorporating aspects of Western medical specialties including women's medicine, oncology, and endocrinology, aiming to develop new treatments and approac1xbet 로그인s to wellness. Through application of scientific principles developed for western medicine, clinical research is being carried out to verify t1xbet 로그인 efficacy of traditional Asian treatments. T1xbet 로그인 Institute is one of Japan's leading research and treatment facilities in t1xbet 로그인 field of women's 1xbet 로그인alth, with a focus on PMS/PMDD. Engaged in a wide range of research including but not limited to traditional Asian medicine, t1xbet 로그인 Institute has publis1xbet 로그인d numerous studies both in Japan and abroad.
Latest Nutraceuti1xbet 로그인l Business related News Releases