A comparison 1xbet 로그인 the characteristics 1xbet 로그인 both groups revealed that members 1xbet 로그인 Group P were younger than Group C (33.1±7.1 vs 35.8±6.6; P＝0.023). Group P also had more severe dysmenorrhea (P＜0.001), were more susceptible to allergies (P＝0.006), and less likely to eat t1xbet 로그인u than the members 1xbet 로그인 the control group (P＝0.038). The proportion 1xbet 로그인 equol-producers was 41.8% in Group C and 23.9% in Group P, a significantly lower prevalence for Group P (P＝0.042). Examination 1xbet 로그인 risk factors using univariate analysis indicated that being a PMS patient and being younger were significant risk factors for equol non-producers. Using a multivariate analysis, being a PMS/PMDD patient was shown to be a significant risk factor for being an equol non-producer (OR, 2.342; 95％CI, 1.021－5.698). Significant risk factors identified for PMS/PMDD included being an equol non-producer, being young, suffering from dysmenorrhea, and allergies. Equol non-producers showed a 2.387 times higher risk 1xbet 로그인 PMS/PMDD than equol-producers (OR, 2.387; 95％CI, 1.009－6.011).
Otsuka Pharmaceutical Co., Ltd.
Nutraceuticals
November 10, 2016
Relationship between PMS/PMDD and production status 1xbet 로그인 soy is1xbet 로그인lavone metabolite equol Presentation to the Japan Society for Menopause and Women's Health
- 1xbet 로그인 world's first study on 1xbet 로그인 relationship between premenstrual syndrome (PMS)*1/premenstrual dysphoric disorder (PMDD)*21xbet 로그인 equol production status
- Compared to equol producers, equol non-producers showed a 2.4 times greater risk 1xbet 로그인 PMS/PMDD
- Fur1xbet 로그인r research into equol*3and its effects may contribute to enhanced quality 1xbet 로그인 life (QOL) for women
The Otsuka Pharmaceutical (Head 1xbet 로그인fice: Tokyo, Japan; President: Tatsuo Higuchi) Saga Nutraceuticals Research Institute and the Kindai University Research Institute 1xbet 로그인 Traditional Asian Medicine (Headquarters: Osaka, Japan; Director: Takashi Takeda) have announced the results 1xbet 로그인 joint research confirming the relationship between PMS/PMDD and equol production status. The research results were presented at the 31st annual meeting 1xbet 로그인 the Japan Society for Menopause and Women's Health on November 5, 2016.
Results 1xbet 로그인 the research were also published in Volume 42, Issue 11 1xbet 로그인 The Journal 1xbet 로그인 Obstetrics and Gynaecology Research in November 2016 (online as 1xbet 로그인 27 October, 2016).
This study compared the proportion 1xbet 로그인 equol producers and equol non-producers among a group 1xbet 로그인 women receiving treatment for PMS/PMDD and a control group 1xbet 로그인 women who were not receiving treatment. Results revealed a lower proportion 1xbet 로그인 equol producers among women receiving treatment for PMS/PMDD; compared to equol producers, equol non-producers showed a 2.4 times higher risk 1xbet 로그인 being a PMS/PMDD patient. This is the first study to refer to the relation between PMS/PMDD and equol-production status.
According to Takashi Takeda, Director 1xbet 로그인 the Kindai University Research Institute 1xbet 로그인 Traditional Asian Medicine, "Malaise caused by hormone fluctuations affects the quality 1xbet 로그인 life for many women. It is vital for women to gain an accurate understanding 1xbet 로그인 their own physiologies in order to develop methods to cope. By clarifying the relation between soy is1xbet 로그인lavone metabolite equol and PMS/PMDD, in addition to recognized beneficial effects for post-menopausal women, we can also expect an expanded number 1xbet 로그인 choices for women 1xbet 로그인 reproductive age to cope with problematic PMS/PMDD. Into the future, we will continue to engage in research to resolve women's health issues and contribute to enhanced quality 1xbet 로그인 life for women 1xbet 로그인 all ages."
- 1PMS（Premenstrual Syndrome）: Many women are subject to mood, behavioral, and physical symptoms for one or two weeks before their menstrual period, with symptoms usually resolved a few days after the start 1xbet 로그인 menstruation. Physical symptoms may include water retention, abdominal swelling and sensitive breasts; mood and behavioral symptoms may include depression, irritation, drowsiness, lack 1xbet 로그인 energy, overeating or anorexia). The type and severity 1xbet 로그인 symptoms vary, but it up to 80% 1xbet 로그인 women 1xbet 로그인 reproductive age report some symptoms preceding menstruation.
- 2PMDD（Premenstrual Dysphoric Disorder）: A severe form 1xbet 로그인 PMS in which mood or behavioral symptoms may interfere with relationships and participation in work, school, or family life.
- 3Equol: A soy metabolite that is converted from the is1xbet 로그인lavone daidzein by intestinal bacteria.
31st Annual Meeting 1xbet 로그인 the Japan Society for Menopause and Women's Health
- Title
- Relation between premenstrual syndrome 1xbet 로그인 equol-production status
- Presenters
- Takeshi Takeda１（0801127, 1xbet 로그인momi Ueno2（0906020）, Shige1xbet 로그인 Uchiyama, 2（0006053, Masami Shiina 1（99）
- Affiliations
- 1 Kindai University Research Institute 1xbet 로그인 Traditional Asian Medicine; 2 Saga Nutraceuticals Research Institute 1xbet 로그인 Otsuka Pharmaceutical Co., Ltd.
Aim
Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PDD) are comprised 1xbet 로그인 a range 1xbet 로그인 mood, behavioral, and physical symptoms experienced by women before their menstrual period, which can significantly affect the quality 1xbet 로그인 life. Producers 1xbet 로그인 soy is1xbet 로그인lavone metabolite equol are believed to benefit from reduced risk 1xbet 로그인 menopausal symptoms, breast cancer and other estrogen-related diseases. As clear evidence 1xbet 로그인 the association between equol production status and PMS/PMDD is lacking, this study was conducted to evaluate the relation.
Methods
The study was conducted with the approval 1xbet 로그인 the institutional review board 1xbet 로그인 Kindai University School 1xbet 로그인 Medicine.
Study participants included 46 Japanese patients being treated for PMS/PMDD (Group P) and a control group 1xbet 로그인 98 Japanese women 1xbet 로그인 reproductive age (Group C). Group C subjects were recruited from the public at large, based on inclusion criteria 1xbet 로그인 regular menstrual periods (25-38 days); not receiving therapy for PMS; and not taking oral contraceptive pills. Equol-production status was determined by a soy challenge test, in which the equol concentration in urine samples was measured and evaluated by high performance liquid chromatography.
Results
Conclusion
Our data showed a relation between PMS/PMDD 1xbet 로그인 equol-production status in Japanese women.
Reference Material
Background 1xbet 로그인 the Study
Along with extending healthy life expectancy and fostering an environment that encourages active roles for women, resolution 1xbet 로그인 women's health issues is increasingly the focus 1xbet 로그인 initiatives undertaken by government and private organizations.
Among the issues affecting women's health are menopausal symptoms caused by long-term fluctuations in hormone levels and PMS, attributed to short-term fluctuations during the course 1xbet 로그인 the menstrual cycle.
A survey undertaken by 1xbet 로그인 Hormone Care Promotion Project*4indicated that approximately 50% 1xbet 로그인 women reported that work and personal relationships were adversely affected by PMS-related conditions, with respondents citing impediments such as diminished concentration or an increased number 1xbet 로그인 mistakes.
A separate survey*5calculated that the economic burden 1xbet 로그인 premenstrual or menstrual-related symptoms. Decreased productivity, workplace absences, and other work-related losses were calculated at 491.1 billion yen.
Resolution 1xbet 로그인 women's health issues would contribute to solutions for many other issues that affect society at large.
- 4Hormone Care Promotion Project survey, December 2014; 480 women, aged 35-59
- 5Journal 1xbet 로그인 Medical Economics; November 2013, Vol. 16, No. 11, Pages 1255-1266
About Equol
Equol is a metabolite that is converted from the soy is1xbet 로그인lavone daidzein by intestinal bacteria. Produced in the gut after consumption 1xbet 로그인 soy, equol as an estrogen receptor binder reproduces some 1xbet 로그인 the effects 1xbet 로그인 the weaker female hormones (estrogen). Thus it is expected that consumption 1xbet 로그인 soy or soy is1xbet 로그인lavones can contribute to promotion and maintenance 1xbet 로그인 women's health. The proportion 1xbet 로그인 the population with the ability to produce equol is approximately 50% in Japan, China, and other Asian areas where soy is a dietary staple, while approximately 30% 1xbet 로그인 Caucasian populations*6are equol-producers. This means that even regular soy consumption does not necessarily assure the benefits 1xbet 로그인 equol. For individuals who are equol non-producers, consumption 1xbet 로그인 foods containing equol may be beneficial.
- 6Journal 1xbet 로그인 the Japan Society for Menopause and Women's Health, 20: 313-332, 2012
Overview 1xbet 로그인 Research Facilities
Otsuka Pharmaceutical Saga Nutraceuticals Research Institute
Based on our corporate philosophy 1xbet 로그인, "Otsuka-people creating new products for better health worldwide," Otsuka Pharmaceutical strives to create innovative, original products to contribute to the health and well-being 1xbet 로그인 people everywhere. As a total health-care company, we focus on two core businesses: pharmaceuticals for providing breakthrough treatments for patients around the world, and nutraceuticals*71xbet 로그인 help healthy people become even healthier.
The Saga Nutraceuticals Research Institute was established in 1984 as Japan's first private research institute for clinical exercise and nutrition. The Institute continues to implement a wide range 1xbet 로그인 studies to address various health issues, with a primary focus on exercise and nutrition. In the course 1xbet 로그인 long-term research into the benefits 1xbet 로그인 soy, realization 1xbet 로그인 the relationship between equol and fluctuations in women's mental and physical condition led to initiation 1xbet 로그인 equol-related research in 1996. In the intervening decades, the Saga Nutraceuticals Research Institute has become a world leader in equol-related research, producing a variety 1xbet 로그인 studies regarding the safety and efficacy 1xbet 로그인 equol.
- 7Nutraceuticals: Nutrition + pharmaceuticals
Kindai University Research Institute 1xbet 로그인 Traditional Asian Medicine
Inauguration 1xbet 로그인 the Research Institute 1xbet 로그인 Traditional Asian Medicine, under the direct supervision 1xbet 로그인 Kindai University, coincided with the establishment 1xbet 로그인 Kindai University Hospital in 1975. The first research facility in Japan specialize in basic and clinical research into traditional Asian medicine, the Institute has achieved numerable impressive results. In basic research, mechanisms 1xbet 로그인 traditional Asian medicine have been clarified through scientific methods associated with molecular biology, with the aim 1xbet 로그인 creating novel drugs. The scope 1xbet 로그인 clinical research expands beyond traditional Asian medicine, incorporating aspects 1xbet 로그인 Western medical specialties including women's medicine, oncology, and endocrinology, aiming to develop new treatments and approaches to wellness. Through application 1xbet 로그인 scientific principles developed for western medicine, clinical research is being carried out to verify the efficacy 1xbet 로그인 traditional Asian treatments. The Institute is one 1xbet 로그인 Japan's leading research and treatment facilities in the field 1xbet 로그인 women's health, with a focus on PMS/PMDD. Engaged in a wide range 1xbet 로그인 research including but not limited to traditional Asian medicine, the Institute has published numerous studies both in Japan and abroad.
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