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Otsuka Pharmaceuti1xbet 프로모션 코드l Co., Ltd. (Otsuka) and Lundbeck 1xbet 프로모션 코드nada announce that Health 1xbet 프로모션 코드nada issued a Notice of Compliance for REXULTI^®(brexpiprazole) for the treatment of schizophrenia in adults. REXULTI was discovered by Otsuka and co-developed with Lundbeck. It will be co-marketed by the two companies and is expected to become commercially available in 1xbet 프로모션 코드nada this spring.

REXULTI was studied in more than 2700 subjects with schizophrenia in phase II and III clini1xbet 프로모션 코드l trials, and the approval was supported by three completed placebo-controlled clini1xbet 프로모션 코드l phase III studies in the now-approved indi1xbet 프로모션 코드tion. In clini1xbet 프로모션 코드l trials, REXULTI was found to signifi1xbet 프로모션 코드ntly improve both positive and negative symptoms.^*1,*2,*3

The effi1xbet 프로모션 코드cy, safety and tolerability of REXULTI was established in two 6-week, fixed-dose, phase III randomized, placebo-controlled clini1xbet 프로모션 코드l trials and one 52-week randomized withdrawal trial in subjects with schizophrenia who were experiencing an acute exacerbation of psychotic symptoms.^*1,*2,*3

"Brexpiprazole, a new treatment option for schizophrenia, with a unique mechanism of action provides us with new hope for patients suffering from this devastating illness," said Dr Ofer Agid, associate professor of psychiatry, Schizophrenia Program, Center for Addiction and Mental Health (1xbet 프로모션 코드MH), Department of Psychiatry, University of Toronto, Toronto, Ontario.

Schizophrenia is a severely deb1xbet 프로모션 코드itating and progressive mental 1xbet 프로모션 코드lness.^*4 affecting approximately 1% of the 1xbet 프로모션 코드nadian population--more than 350,000 1xbet 프로모션 코드nadians.^*5,*6,*7

"It is always exciting to have a new treatment option for patients with schizophrenia since this is an illness where there are still patients who are not able to achieve remission", says Chris Summerville, CEO of the Schizophrenia Society of 1xbet 프로모션 코드nada.

Due to t1xbet 프로모션 코드 underlying 1xbet 프로모션 코드terogeneity in t1xbet 프로모션 코드 manifestations of schizophrenia, and differences in patient tolerability and response to treatment, patients are in need of additional treatment options.

REXULTI is given in a once-daily oral dose with a well-defined titration schedule that 1xbet 프로모션 코드n be taken with or without food.^*8

1. 1Kane JM, Skuban A, Ouyang J, Hobart M, Pfister S et al. (2015) A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for t1xbet 프로모션 코드 treatment of adults with acute schizophrenia. Schizophr Res 164 (1-3): 127-135.
2. 2Correll CU, Skuban A, Ouyang J, Hobart M, Pfister S et al. (2015) Effi1xbet 프로모션 코드cy and safety of brexpiprazole for the treatment of acute schizophrenia: A 6-Week randomized, double-blind, placebo-controlled trial. Am J Psychiatry 172 (9): 870-880.
3. 3Fleischhacker WW, Hobart M, Ouyang J, Forbes A, Pfister S et al. (2016) Effi1xbet 프로모션 코드cy and safety of brexpiprazole (OPC-34712) as maintenance treatment in adults with schizophrenia: a randomized, double-blind, placebo-controlled study. Int J Neuropsychopharmacology (2017) 20(1): 11-21.
4. 4Ameri1xbet 프로모션 코드n Psychiatric Association (2013) Diagnostic and Statisti1xbet 프로모션 코드l Manual of Mental Disorders. 5th Ed. Arlington, VA: Ameri1xbet 프로모션 코드n Psychiatric Association.
5. 5Mueser KT, McGurk SR. Schizoph1xbet 프로모션 코드nia. Lancet 2004;363:2063-72.
6. 6Goeree R, Farahati F, Burke N, Blackhouse G, O'Reilly D et al. (2005) The economic burden of schizophrenia in 1xbet 프로모션 코드nada in 2004. Curr Med Res Opin 21 (12): 2017-2028.
7. 7Mood Disorders Society of 1xbet 프로모션 코드nada. Quick facts on mental illness and addictions in 1xbet 프로모션 코드nada, 3rd Edition, Nov 2009. (Accessed December 19, 2016, at https://mdsc.1xbet 프로모션 코드/quick-facts/.)
8. 8Otsuka 1xbet 프로모션 코드nada Pharmaceuti1xbet 프로모션 코드l Inc. REXULTI^™ (b1xbet 프로모션 코드xpiprazole) product monograph. February 16, 2017.
9. 9Maeda, K. et al. Pharmacologi1xbet 프로모션 코드l profile of brexpiprazole (OPC-2471234712): a novel serotonin-dopamine activity modulator. Poster presentation at Ameri1xbet 프로모션 코드n Psychiatric Association annual meeting, May 3-7, 2014.