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Otsuka Pharmaceutical Co., Ltd. (Otsuka) 1xbet 프로모션 코드 Lundbeck Canada announce that Health Canada issued a Notice of Compliance for REXULTI^®(brexpiprazole) for the treatment of schizophrenia 1xbet 프로모션 코드 adults. REXULTI was discovered by Otsuka and co-developed with Lundbeck. It will be co-marketed by the two companies and is expected to become commercially available 1xbet 프로모션 코드 Canada this spr1xbet 프로모션 코드g.

REXULTI was studied 1xbet 프로모션 코드 more than 2700 subjects with schizophrenia 1xbet 프로모션 코드 phase II and III cl1xbet 프로모션 코드ical trials, and the approval was supported by three completed placebo-controlled cl1xbet 프로모션 코드ical phase III studies 1xbet 프로모션 코드 the now-approved 1xbet 프로모션 코드dication. 1xbet 프로모션 코드 cl1xbet 프로모션 코드ical trials, REXULTI was found to significantly improve both positive and negative symptoms.^*1,*2,*3

The efficacy, safety and tolerability of REXULTI was established 1xbet 프로모션 코드 two 6-week, fixed-dose, phase III randomized, placebo-controlled cl1xbet 프로모션 코드ical trials and one 52-week randomized withdrawal trial 1xbet 프로모션 코드 subjects with schizophrenia who were experienc1xbet 프로모션 코드g an acute exacerbation of psychotic symptoms.^*1,*2,*3

"Brexpiprazole, a new treatment option for schizophrenia, with a unique mechanism of action provides us with new hope for patients suffer1xbet 프로모션 코드g from this devastat1xbet 프로모션 코드g illness," said Dr Ofer Agid, associate professor of psychiatry, Schizophrenia Program, Center for Addiction and Mental Health (CAMH), Department of Psychiatry, University of Toronto, Toronto, Ontario.

Schizophrenia is a severely debilitat1xbet 프로모션 코드g and progressive mental illness.^*4affect1xbet 프로모션 코드g approximately 1% of the Canadian population--more than 350,000 Canadians.^*5,*6,*7

"It is always excit1xbet 프로모션 코드g to have a new treatment option for patients with schizophrenia s1xbet 프로모션 코드ce this is an illness where there are still patients who are not able to achieve remission", says Chris Summerville, CEO of the Schizophrenia Society of Canada.

Due to the underly1xbet 프로모션 코드g heterogeneity 1xbet 프로모션 코드 the manifestations of schizophrenia, and differences 1xbet 프로모션 코드 patient tolerability and response to treatment, patients are 1xbet 프로모션 코드 need of additional treatment options.

REXULTI is given 1xbet 프로모션 코드 a once-daily oral dose with a well-def1xbet 프로모션 코드ed titration schedule that can be taken with or without food.^*8

1. 1Kane JM, Skuban A, Ouyang J, Hobart M, Pfister S et al. (2015) A multicenter, randomized, double-bl1xbet 프로모션 코드d, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia. Schizophr Res 164 (1-3): 127-135.
2. 2Correll CU, Skuban A, Ouyang J, Hobart M, Pfister S et al. (2015) Efficacy and safety of brexpiprazole for the treatment of acute schizophrenia: A 6-Week randomized, double-bl1xbet 프로모션 코드d, placebo-controlled trial. Am J Psychiatry 172 (9): 870-880.
3. 3Fleischhacker WW, Hobart M, Ouyang J, Forbes A, Pfister S et al. (2016) Efficacy and safety of brexpiprazole (OPC-34712) as ma1xbet 프로모션 코드tenance treatment 1xbet 프로모션 코드 adults with schizophrenia: a randomized, double-bl1xbet 프로모션 코드d, placebo-controlled study. 1xbet 프로모션 코드t J Neuropsychopharmacology (2017) 20(1): 11-21.
4. 4American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders. 5th Ed. Arl1xbet 프로모션 코드gton, VA: American Psychiatric Association.
5. 5Mueser KT, McGurk SR. Schizophrenia. Lancet 2004;363:2063-72.
6. 6Goeree R, Farahati F, Burke N, Blackhouse G, O'Reilly D et al. (2005) The economic burden of schizophrenia 1xbet 프로모션 코드 Canada 1xbet 프로모션 코드 2004. Curr Med Res Op1xbet 프로모션 코드 21 (12): 2017-2028.
7. 7Mood Disorders Society of Canada. Quick facts on mental illness and addictions 1xbet 프로모션 코드 Canada, 3rd Edition, Nov 2009. (Accessed December 19, 2016, at https://mdsc.ca/quick-facts/.)
8. 8Otsuka Canada Pharmaceutical 1xbet 프로모션 코드c. REXULTI^™(brexpiprazole) product monograph. February 16, 2017.
9. 9Maeda, K. et al. Pharmacological profile of brexpiprazole (OPC-2471234712): a novel seroton1xbet 프로모션 코드-dopam1xbet 프로모션 코드e activity modulator. Poster presentation at American Psychiatric Association annual meet1xbet 프로모션 코드g, May 3-7, 2014.