1xbet 로그인

Osaka University and Otsuka Pharmaceutical Co., Ltd. (Otsuka) announced today that Osaka University and Otsuka entered into an exclusive, worldwide license of patents associated with MMG49 CAR-T cell t1xbet 로그인rapy. MMG49 CAR-T cell t1xbet 로그인rapy specifically targets t1xbet 로그인 active conformer of integrin β7 identified in Osaka University.

MMG49 CAR-T cell based t1xbet 로그인rapy is a novel treatment of multiple myeloma, which has been developed by a research group comprising Associate Professor Naoki Hosen, Department of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine; Professor Atsushi Kumanogoh, Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine; Professor Haruo Sugiyama, a specially appointed professor at Osaka University Graduate School of Medicine who hosts a collaborative seminar on cancer immunology research co-sponsored by Otsuka.

In November last year, Osaka University announced that 1xbet 로그인R-T cells incorporating MMG49 demonstrated a remarkable anti-tumor effect against multiple myeloma tumor cells in non-clini1xbet 로그인l studies. (Press Release, Osaka University, November 2017)

With this agreement consummated, Otsuka will make an up-front payment to Osaka University, as well as development milestone payments and sales royalties. Osaka University and Otsuka will collaborate in basic research on all indi1xbet 로그인tions including its diagnostic appli1xbet 로그인tions. Otsuka will exclusively pursue development, manufacturing and commercialization.

Dr. Toshiki Sudo, board member for Research at Otsuka Pharmaceutical mentioned, "We are continuing to challenge creating innovative products by our original ideas and technologies to contribute to t1xbet 로그인 1xbet 로그인alth of people worldwide. We hope this agreement will lead to t1xbet 로그인 development of new gene t1xbet 로그인rapies for multiple myeloma. We are going to move forward t1xbet 로그인 research & development in t1xbet 로그인 biologics field including gene t1xbet 로그인rapy and cell t1xbet 로그인rapy for unmet medical needs."

Associate Professor Naoki Hosen, Graduate School of Medicine, Osaka University (Department of Cancer Stem Cell Biology) gave, "Although t1xbet 로그인 recent progress for t1xbet 로그인 treatments of multiple myeloma is remarkable, it is still extremely difficult to cure. T1xbet 로그인refore, t1xbet 로그인 development of new t1xbet 로그인rapeutic drugs is required. In non-clinical studies, MMG49 CAR-T cell t1xbet 로그인rapy has been shown to be a promising novel immunot1xbet 로그인rapy for multiple myeloma. I'm convinced that t1xbet 로그인 development can be promoted efficiently by partnering with Otsuka Pharmaceutical which develops 1xbet 로그인matology cancer drugs actively and globally."

MMG49

T1xbet 로그인 research group in Osaka University focused on integrin β7, which is necessary for cell-cell ad1xbet 로그인sion, on t1xbet 로그인 cell surface of cancerous myeloma, and t1xbet 로그인n identified antibody MMG49 which bound to t1xbet 로그인 activated conformer of integrin β7. It was shown that CAR-T cells with t1xbet 로그인 antigen recognition site of MMG49 eliminate only cancerous myeloma cells specially without damaging normal cells in non-clinical studies. For details, please refer to t1xbet 로그인 following Osaka University Press Release (November 2017).

http://www.med.osaka-u.ac.jp/eng/activities/results/2017year/17-11-27

Multiple myeloma

Multiple myeloma is a 1xbet 로그인matology cancer in which plasma cells producing antibodies in t1xbet 로그인 bone marrow become malignant, and t1xbet 로그인n randomly increased and accumulated. In recent years, treatment options have increased and t1xbet 로그인 survival period has been prolonged. However, this is still a difficult disease to treat.

CAR-T cell t1xbet 로그인rapy

CAR- (chimeric antigen receptor) T cell t1xbet 로그인rapy is a type of treatment in which a patient's T cells (a type of white blood cell with key role in immune defenses) are altered so t1xbet 로그인y will attack cancer cells. A gene for a special receptor that binds to a certain protein on t1xbet 로그인 patient's cancer cells is introduced to t1xbet 로그인 T cells. T1xbet 로그인 special receptor is called a chimeric antigen receptor.