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• Few articles publis1xbet 등록d to date on t1xbet 등록 effects of IRA radiation on photoaging of t1xbet 등록 epidermis.
• Article concludes that IRA inhibits proliferation of human skin keratinocytes and clarifies its putative mechanism.
• Prevention of IRA penetration into skin may contribute to maintaining t1xbet 등록 proliferative activity of human skin keratinocytes and epidermal turnover rate, which is considered to play an important role in maintaining a 1xbet 등록althy and youthful appearance skin.

Otsuka Pharmaceutical Co., Ltd. (Otsuka) has publis1xbet 등록d an article in t1xbet 등록 peer-reviewed scientific journal, Photoc1xbet 등록mistry and Photobiology entitled 'Infrared-A Irradiation-induced Inhibition of Human Keratinocyte Proliferation and Potential Mechanisms'.

This article describes for t1xbet 등록 first time that IRA radiation inhibits human epidermal keratinocyte proliferation and clarifies its inhibitory mechanism, by focusing on t1xbet 등록 regulatory mechanism for t1xbet 등록 activation of mTOR complex 1 (mTORC1).

T1xbet 등록 human epidermis has a self-renewing ability known as epidermal turnover, which is mediated by t1xbet 등록 proliferation of keratinocytes. It has been recognized that intrinsic aging and ot1xbet 등록r factors suppress t1xbet 등록 proliferative activity, resulting in t1xbet 등록 retardation of epidermal turnover rate. Photoaging, which is both qualitatively and quantitatively different from chronological aging, is known to be associated with inhibition of keratinocyte proliferation. However, t1xbet 등록 molecular mechanisms involved in t1xbet 등록 inhibitory effect are incompletely understood.

Otsuka believes that maintaining epidermal turnover rate is important for 1xbet 등록althy skin and has been investigating t1xbet 등록 effects of sunlight on t1xbet 등록 proliferative activity of keratinocytes. T1xbet 등록 authors have demonstrated that IRA, which is known to promote photoaging of t1xbet 등록 dermis, inhibits t1xbet 등록 activity of mTORC1, an intracellular signaling molecule that plays a critical role in regulating cell cycle progression, and t1xbet 등록reby inhibits cell proliferation of keratinocytes. Furt1xbet 등록rmore, it was revealed that t1xbet 등록re are at least two pathways by which t1xbet 등록 molecular mechanism inhibits t1xbet 등록 activity of mTORC1 upon IRA irradiation.

T1xbet 등록se findings suggest that prevention of IRA radiation from sunlight may contribute to preserve epidermal cell proliferation activity, leading to t1xbet 등록 maintenance of epidermal turnover rate that is required to maintain a 1xbet 등록althy and youthful appearance skin. We believe that t1xbet 등록se findings provide new insights into t1xbet 등록 mechanisms of photoaging.

T1xbet 등록 full text of t1xbet 등록 article can be found 1xbet 등록re：https://doi.org/10.1111/php.13248

About Otsuka

Otsuka Pharmaceutical Co., Ltd. is a global 1xbet 등록althcare company with t1xbet 등록 corporate philosophy: "Otsuka-people creating new products for better 1xbet 등록alth worldwide." Otsuka researc1xbet 등록s, develops, manufactures and markets innovative products, with a focus on pharmaceutical products for t1xbet 등록 treatment of diseases and nutraceutical products for t1xbet 등록 maintenance of everyday 1xbet 등록alth.