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• Few articles published to date on the effects 1xbet 등록 IRA radiation on photoaging 1xbet 등록 the epidermis.
• Article concludes that IRA inhibits proliferation 1xbet 등록 human skin keratinocytes and clarifies its putative mechanism.
• Prevention 1xbet 등록 IRA penetration into skin may contribute to maintaining the proliferative activity 1xbet 등록 human skin keratinocytes and epidermal turnover rate, which is considered to play an important role in maintaining a healthy and youthful appearance skin.

1xbet 등록 Pharmaceutical Co., Ltd. (1xbet 등록) has published an article in the peer-reviewed scientific journal,Photochemistry 1xbet 등록 Photobiologyentitled 'Infrared-A Irradiation-induced Inhibition 1xbet 등록 Human Keratinocyte Proliferation and Potential Mechanisms'.

This article describes for the first time that IRA radiation inhibits human epidermal keratinocyte proliferation and clarifies its inhibitory mechanism, by focusing on the regulatory mechanism for the activation 1xbet 등록 mTOR complex 1 (mTORC1).

The human epidermis has a self-renewing ability known as epidermal turnover, which is mediated by the proliferation 1xbet 등록 keratinocytes. It has been recognized that intrinsic aging and other factors suppress the proliferative activity, resulting in the retardation 1xbet 등록 epidermal turnover rate. Photoaging, which is both qualitatively and quantitatively different from chronological aging, is known to be associated with inhibition 1xbet 등록 keratinocyte proliferation. However, the molecular mechanisms involved in the inhibitory effect are incompletely understood.

Otsuka believes that maintaining epidermal turnover rate is important for healthy skin and has been investigating the effects 1xbet 등록 sunlight on the proliferative activity 1xbet 등록 keratinocytes. The authors have demonstrated that IRA, which is known to promote photoaging 1xbet 등록 the dermis, inhibits the activity 1xbet 등록 mTORC1, an intracellular signaling molecule that plays a critical role in regulating cell cycle progression, and thereby inhibits cell proliferation 1xbet 등록 keratinocytes. Furthermore, it was revealed that there are at least two pathways by which the molecular mechanism inhibits the activity 1xbet 등록 mTORC1 upon IRA irradiation.

These findings suggest that prevention 1xbet 등록 IRA radiation from sunlight may contribute to preserve epidermal cell proliferation activity, leading to the maintenance 1xbet 등록 epidermal turnover rate that is required to maintain a healthy and youthful appearance skin. We believe that these findings provide new insights into the mechanisms 1xbet 등록 photoaging.

The full text 1xbet 등록 the article can be found here：https://doi.org/10.1111/php.13248

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Otsuka Pharmaceutical Co., Ltd. is a global healthcare company with the corporate philosophy: "Otsuka-people creating new products for better health worldwide." Otsuka researches, develops, manufactures and markets innovative products, with a focus on pharmaceutical products for the treatment 1xbet 등록 diseases and nutraceutical products for the maintenance 1xbet 등록 everyday health.