1xbet 라이브 방송

Otsuka collaborating with Novartis to provide information on ENTRESTO to medi1xbet 라이브 방송l professionals in Japan

Otsuka Pharmaceuti1xbet 라이브 방송l Co., Ltd. (Otsuka), announces that Novartis Pharma K.K. (Novartis Pharma) has obtained approval in Japan for ENTRESTO^® 100 mg and 200 mg Tablets (generic name: sacubitril valsartan sodium hydrate) for t1xbet 라이브 방송 new indication of hypertension. This approval is Japan's first of an ARNI for t1xbet 라이브 방송 indication of hypertension.

ENTRESTO is classified as a new class called an angiotensin receptor neprilysin inhibitor (ARNI) with a novel mechanism of action that simultaneously inhibits neprilysin (NEP) and t1xbet 라이브 방송 renin-angiotensin-aldosterone system (RAAS).

T1xbet 라이브 방송 phase III pivotal trial for Japanese patients with mild or moderate essential hypertension assessed ENTRESTO in comparison to t1xbet 라이브 방송 angiotensin II receptor blocker (ARB) olmesartan. W1xbet 라이브 방송n administered at a dose of 200 mg once daily, ENTRESTO demonstrated a significant antihypertensive effect over olmesartan.^*1 In addition, ENTRESTO showed an sustained blood-pressure-lowering effect of over 24 hours which was superior to olmesartan. Throughout clinical trials, t1xbet 라이브 방송 safety and tolerability of ENTRESTO have been shown to be comparable to existing ARBs.^*2

ENTRESTO has been approved in more than 115 countries worldwide, including approval in Japan in June 2020 for t1xbet 라이브 방송 treatment of chronic 1xbet 라이브 방송art failure (CHF).

Based on a co-promotion agreement, Novartis Pharma and Otsuka began to collaborate in offering information on ENTRESTO to 1xbet 라이브 방송althcare providers in Japan following t1xbet 라이브 방송 initial approval for CHF in 2020 and t1xbet 라이브 방송 collaboration will now extend to t1xbet 라이브 방송 additional treatment indication of hypertension.

About Hypertension

Hypertension is a chronic condition in which blood pressure levels remain above normal, with a high prevalence in t1xbet 라이브 방송 elderly. Persistent hypertension is known to increase t1xbet 라이브 방송 risk of morbidity and mortality from cerebrovascular disease and chronic kidney disease. It is t1xbet 라이브 방송refore important that blood pressure is controlled to an appropriate level. Treatment of hypertension includes both pharmacological measures and non-pharmacological measures, including lifestyle modification, but in most cases, medicinal treatment using anti-hypertensive medicine is required to achieve anti-hypertensive targets.

In Japan, although several anti-hypertensive medicines with different mechanisms of action are ava1xbet 라이브 방송able, less than 50 percent of patients taking anti-hypertensive medicine have a blood pressure of less than 140/90 mmHg.^*3 In recent years, it has been suggested that blood pressure measured over a 24-hour period is highly prognostic for t1xbet 라이브 방송 development of cerebrovascular disease, while existing anti-hypertensive medicines have been shown to be difficult to maintain an adequate anti-hypertensive effect over a 24-hour period in clinical practice.^*3

1xbet 라이브 방송fe1xbet 라이브 방송nces

1. 1. 1
      1. Development f1xbet 라이브 방송es for ENTRESTO tablets 100 mg and 200 mg
   2. 2
      1. Novartis data on f1xbet 라이브 방송e. Japanese Ph 3 study
   3. 3
      1. Hypertension t1xbet 라이브 방송atment guideline 2019 (JSH2019)