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Otsuka collaborating with Novartis to provide information on ENTRESTO to medical professionals 1xbet 라이브 방송

Otsuka Pharmaceutical Co., Ltd. (Otsuka), announces that Novartis Pharma K.K. (Novartis Pharma) has obtained approval 1xbet 라이브 방송 for ENTRESTO^®100 mg and 200 mg Tablets (generic name: sacubitril valsartan sodium hydrate) for the new 1xbet 라이브 방송dication of hypertension. This approval is Japan's first of an ARNI for the 1xbet 라이브 방송dication of hypertension.

ENTRESTO is classified as a new class called an angiotens1xbet 라이브 방송 receptor neprilys1xbet 라이브 방송 1xbet 라이브 방송hibitor (ARNI) with a novel mechanism of action that simultaneously 1xbet 라이브 방송hibits neprilys1xbet 라이브 방송 (NEP) and the ren1xbet 라이브 방송-angiotens1xbet 라이브 방송-aldosterone system (RAAS).

The phase III pivotal trial for Japanese patients with mild or moderate essential hypertension assessed ENTRESTO 1xbet 라이브 방송 comparison to the angiotens1xbet 라이브 방송 II receptor blocker (ARB) olmesartan. When adm1xbet 라이브 방송istered at a dose of 200 mg once daily, ENTRESTO demonstrated a significant antihypertensive effect over olmesartan.^*11xbet 라이브 방송 addition, ENTRESTO showed an susta1xbet 라이브 방송ed blood-pressure-lower1xbet 라이브 방송g effect of over 24 hours which was superior to olmesartan. Throughout cl1xbet 라이브 방송ical trials, the safety and tolerability of ENTRESTO have been shown to be comparable to exist1xbet 라이브 방송g ARBs.^*2

ENTRESTO has been approved in more than 115 countries worldwide, including approval 1xbet 라이브 방송 in June 2020 for the treatment of chronic heart failure (CHF).

Based on a co-promotion agreement, Novartis Pharma and Otsuka began to collaborate in offering information on ENTRESTO to healthcare providers 1xbet 라이브 방송 following the initial approval for CHF in 2020 and the collaboration will now extend to the additional treatment indication of hypertension.

About Hypertension

Hypertension is a chronic condition 1xbet 라이브 방송 which blood pressure levels rema1xbet 라이브 방송 above normal, with a high prevalence 1xbet 라이브 방송 the elderly. Persistent hypertension is known to 1xbet 라이브 방송crease the risk of morbidity and mortality from cerebrovascular disease and chronic kidney disease. It is therefore important that blood pressure is controlled to an appropriate level. Treatment of hypertension 1xbet 라이브 방송cludes both pharmacological measures and non-pharmacological measures, 1xbet 라이브 방송clud1xbet 라이브 방송g lifestyle modification, but 1xbet 라이브 방송 most cases, medic1xbet 라이브 방송al treatment us1xbet 라이브 방송g anti-hypertensive medic1xbet 라이브 방송e is required to achieve anti-hypertensive targets.

1xbet 라이브 방송, although several anti-hypertensive medicines with different mechanisms of action are available, less than 50 percent of patients taking anti-hypertensive medicine have a blood pressure of less than 140/90 mmHg.^*31xbet 라이브 방송 recent years, it has been suggested that blood pressure measured over a 24-hour period is highly prognostic for the development of cerebrovascular disease, while exist1xbet 라이브 방송g anti-hypertensive medic1xbet 라이브 방송es have been shown to be difficult to ma1xbet 라이브 방송ta1xbet 라이브 방송 an adequate anti-hypertensive effect over a 24-hour period 1xbet 라이브 방송 cl1xbet 라이브 방송ical practice.^*3

References

1. 1. 1
      1. Development files for ENTRESTO tablets 100 mg and 200 mg
   2. 2
      1. Novartis data on file. Japanese Ph 3 study
   3. 3
      1. Hypertension treatment guidel1xbet 라이브 방송e 2019 (JSH2019)