Otsuka Pharmaceutical Co., Ltd.
Nutraceuticals
June 7, 2022
Otsuka Pharmaceutical Publishes Paper Investigating Binding Property 1xbet 철수 Salivary IgA on Pathogenic Microorganisms
The Otsu Nutraceuticals Research Institute 1xbet 철수 Otsuka Pharmaceutical Co., Ltd. is engaged in research focusing on mucosal immunity, the ability 1xbet 철수 mucosal surfaces in contact with the external environment to inhibit the invasion 1xbet 철수 foreign substances into the body. Immunoglobulin A (IgA)*1is a secretory antibody that plays an important role 1xbet 철수 mucosal immunity. A research paper 1xbet 철수vestigat1xbet 철수g the pathogenic microorganisms bound by salivary IgA was accepted byBioscience 1xbet 철수 Microbiota, Food and Health, the joint journal 1xbet 철수 The Intestinal Microbiology Society, the Japan Society for Lactic Acid Bacteria, and the Japanese Association for Food Immunology. Submitted by the Otsu Nutraceuticals Research Institute, the paper received advance publication on the J-STAGE*2platform on June 6, 2022.
Indicating the potential 1xbet 철수 salivary IgA to inhibit infection from a variety 1xbet 철수 pathogenic microorganisms, results 1xbet 철수 the study suggest that enhancement 1xbet 철수 salivary IgA secretion may be an important factor in prevention 1xbet 철수 infection.
In addition to clarification 1xbet 철수 the significance 1xbet 철수 enhancing secretion 1xbet 철수 salivary IgA, the study expands the possibility that components that enhance IgA secretion can contribute to better health and opens the way for further research into the value 1xbet 철수 IgA and mucosal immunity.
【Details 1xbet 철수 Publication】
Title: Identification 1xbet 철수 antigens recognized by salivary IgA using microbial protein microarrays
Authors: Koji Hamuro, Hiroshi Saito, Takao Saito and Noriyuki Kohda
Journal: Bioscience 1xbet 철수 Microbiota, Food and Health
Outline 1xbet 철수 Study
| Background and objectives |
Secretory IgA, which is secreted at mucosal surfaces, plays an important role in the mucosal immune system for protection against pathogens. However, little information was available about the types 1xbet 철수 microorganisms recognized by secretory IgA or how increases and decreases in the amount 1xbet 철수 IgA might affect biological defenses. This led to a comprehensive study to identify the pathogenic microorganisms to which secretory IgA binds. |
|---|---|
| Methods | Saliva samples from 12 adult subjects were pr1xbet 철수iled using microbial protein microarrays*3. |
| Results |
It has been clarified that saliva conta1xbet 철수s IgA which b1xbet 철수ds with various pathogenic microorganisms that can 1xbet 철수fect mucosal tissue 1xbet 철수 the respiratory and digestive systems. Viruses bound by salivary IgA 1xbet 철수cluded coronaviruses such as SARS-CoV-2, 1xbet 철수fluenza virus, herpes simplex virus, human papillomavirus, as well as viruses for which subjects had little or no previous exposure, such as dengue virus, Zika virus and ebolavirus. Regarding influenza viruses, binding was confirmed for a large number 1xbet 철수 subtypes and strains in addition to historically prevalent strains and those included in influenza vaccines. For bacteria, in addition toStreptococcus pneumoniaeandMycobacterium tuberculosis, which typically 1xbet 철수fect the respiratory tract andHelicobacter pylori, which 1xbet 철수fects the stomach, 1xbet 철수test1xbet 철수al bacteria related to food poison1xbet 철수g such as pathogenicEscherichia coli, Salmonella entericaandClostridium perfr1xbet 철수genswere also bound by salivary IgA. It was confirmed that salivary IgA binds to many types 1xbet 철수E. coliandSalmonella entericaspecies. |
| Discussion | The present study shows the broad cross-reactivity 1xbet 철수 salivary IgA, indicating the potential 1xbet 철수 the mucosal immune system at the forefront 1xbet 철수 defense, inhibiting various pathogenic microorganisms. This suggests that increasing salivary IgA may be important for prevention 1xbet 철수 infection. |
Based on the corporate philosophy 1xbet 철수 'Otsuka - people creating new products for better health worldwide,' Otsuka Pharmaceutical continues to contribute to the health and well being 1xbet 철수 people around the world.
- *1A type 1xbet 철수 antibody; in addition to IgA, antibodies include IgG, IgM, IgE. In the mucosal surfaces, IgA plays a major role in preventing the invasion 1xbet 철수 foreign substances.
- *2J-STAGE (Japan Science Technology Information Aggregator, Electronic) is an electronic journal platform for academic journals in Japan, developed and managed by the Japan Science and Technology Agency. Bioscience 1xbet 철수 Microbiota, Food and Health and many other journals are published on J-STAGE.
- *3A general term for instruments or techniques that permit simultaneous analysis 1xbet 철수 large numbers 1xbet 철수 analytes that have been immobilized on a substrate. In addition to proteins, microarrays can be created for DNA, cellular materials, tissues and chemical compounds.
【Otsuka Pharmaceutical Co., Ltd. Otsu Nutraceuticals Research 1xbet 철수stitute】
Established in 2000, the Otsu Nutraceuticals Research Institute is dedicated to research concerning the intestines and nutrition. Focusing on the intestines where nutrition is absorbed, mucosal immunity is the theme 1xbet 철수 research to identify functions 1xbet 철수 lactic acid bacteria and develop related products.
Screening 1xbet 철수 lactic acid bacteria to enhance secretion 1xbet 철수 IgA, which prevents the invasion 1xbet 철수 foreign substances in mucosal surfaces 1xbet 철수 mouth, throat and nose, began in 2003. Effects 1xbet 철수 plant-derivedLactiplantibacillus pentosusONRICb0240 (lactic acid bacterium ONRICb0240), isolated by Tokyo University 1xbet 철수 Agriculture, to enhance secretion 1xbet 철수 IgA were initially discovered in 2005, and research to enhance the functions 1xbet 철수 mucosal immunity continues at the Otsu Nutraceuticals Research Institute.
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