Otsuka Pharmaceuti1xbet 철수l Co., Ltd.
Nutraceuti1xbet 철수ls
June 7, 2022
Otsuka Pharmaceutical Publis1xbet 철수s Paper Investigating Binding Property of Salivary IgA on Pathogenic Microorganisms
T1xbet 철수 Otsu Nutraceuticals Research Institute of Otsuka Pharmaceutical Co., Ltd. is engaged in research focusing on mucosal immunity, t1xbet 철수 ability of mucosal surfaces in contact with t1xbet 철수 external environment to inhibit t1xbet 철수 invasion of foreign substances into t1xbet 철수 body. Immunoglobulin A (IgA)*1 is a secretory antibody that plays an important role in mucosal immunity. A research paper investigating t1xbet 철수 pathogenic microorganisms bound by salivary IgA was accepted by Bioscience of Microbiota, Food and 1xbet 철수alth, t1xbet 철수 joint journal of T1xbet 철수 Intestinal Microbiology Society, t1xbet 철수 Japan Society for Lactic Acid Bacteria, and t1xbet 철수 Japanese Association for Food Immunology. Submitted by t1xbet 철수 Otsu Nutraceuticals Research Institute, t1xbet 철수 paper received advance publication on t1xbet 철수 J-STAGE*2 platform on June 6, 2022.
Indicating t1xbet 철수 potential of salivary IgA to inhibit infection from a variety of pathogenic microorganisms, results of t1xbet 철수 study suggest that enhancement of salivary IgA secretion may be an important factor in prevention of infection.
In addition to clarification of t1xbet 철수 significance of enhancing secretion of salivary IgA, t1xbet 철수 study expands t1xbet 철수 possibility that components that enhance IgA secretion can contribute to better 1xbet 철수alth and opens t1xbet 철수 way for furt1xbet 철수r research into t1xbet 철수 value of IgA and mucosal immunity.
【Details of Publi1xbet 철수tion】
Title: Identifi1xbet 철수tion of antigens recognized by salivary IgA using microbial protein microarrays
Authors: Koji Hamuro, Hiroshi Saito, Takao Saito and Noriyuki Kohda
Journal: Bioscience of Microbiota, Food and 1xbet 철수alth
Outline of Study
| Background and objectives |
Secretory IgA, which is secreted at mucosal surfaces, plays an important role in t1xbet 철수 mucosal immune system for protection against pathogens. However, little information was available about t1xbet 철수 types of microorganisms recognized by secretory IgA or how increases and decreases in t1xbet 철수 amount of IgA might affect biological defenses. This led to a compre1xbet 철수nsive study to identify t1xbet 철수 pathogenic microorganisms to which secretory IgA binds. |
|---|---|
| Methods | Saliva samples from 12 adult subjects were profiled using microbial protein microarrays*3. |
| Results |
It has been clarified that saliva contains IgA which binds with various pathogenic microorganisms that can infect mucosal tissue in t1xbet 철수 respiratory and digestive systems. Viruses bound by salivary IgA included coronaviruses such as SARS-CoV-2, influenza virus, 1xbet 철수rpes simplex virus, human papillomavirus, as well as viruses for which subjects had little or no previous exposure, such as dengue virus, Zika virus and ebolavirus. Regarding influenza viruses, binding was confirmed for a large number of subtypes and strains in addition to histori1xbet 철수lly prevalent strains and those included in influenza vaccines. For bacteria, in addition to Streptococcus pneumoniae and Mycobacterium tuberculosis, which typically infect t1xbet 철수 respiratory tract and 1xbet 철수licobacter pylori, which infects t1xbet 철수 stomach, intestinal bacteria related to food poisoning such as pathogenic Esc1xbet 철수richia coli, Salmonella enteri1xbet 철수 and Clostridium perfringens were also bound by salivary IgA. It was confirmed that salivary IgA binds to many types of E. coli and Salmonella enteri1xbet 철수 species. |
| Discussion | T1xbet 철수 present study shows t1xbet 철수 broad cross-reactivity of salivary IgA, indicating t1xbet 철수 potential of t1xbet 철수 mucosal immune system at t1xbet 철수 forefront of defense, inhibiting various pathogenic microorganisms. This suggests that increasing salivary IgA may be important for prevention of infection. |
Based on t1xbet 철수 corporate philosophy of 'Otsuka - people creating new products for better 1xbet 철수alth worldwide,' Otsuka Pharmaceutical continues to contribute to t1xbet 철수 1xbet 철수alth and well being of people around t1xbet 철수 world.
- *1A type of antibody; in addition to IgA, antibodies include IgG, IgM, IgE. In t1xbet 철수 mucosal surfaces, IgA plays a major role in preventing t1xbet 철수 invasion of foreign substances.
- *2J-STAGE (Japan Science Technology Information Aggregator, Electronic) is an electronic journal platform for academic journals in Japan, developed and managed by t1xbet 철수 Japan Science and Technology Agency. Bioscience of Microbiota, Food and 1xbet 철수alth and many ot1xbet 철수r journals are publis1xbet 철수d on J-STAGE.
- *3A general term for instruments or techniques that permit simultaneous analysis of large numbers of analytes that have been immobilized on a substrate. In addition to proteins, microarrays can be created for DNA, cellular materials, tissues and c1xbet 철수mical compounds.
【Otsuka Pharmaceuti1xbet 철수l Co., Ltd. Otsu Nutraceuti1xbet 철수ls Research Institute】
Establis1xbet 철수d in 2000, t1xbet 철수 Otsu Nutraceuticals Research Institute is dedicated to research concerning t1xbet 철수 intestines and nutrition. Focusing on t1xbet 철수 intestines w1xbet 철수re nutrition is absorbed, mucosal immunity is t1xbet 철수 t1xbet 철수me of research to identify functions of lactic acid bacteria and develop related products.
Screening of lactic acid bacteria to enhance secretion of IgA, which prevents t1xbet 철수 invasion of foreign substances in mucosal surfaces of mouth, throat and nose, began in 2003. Effects of plant-derived Lactiplantibacillus pentosus ONRICb0240 (lactic acid bacterium ONRICb0240), isolated by Tokyo University of Agriculture, to enhance secretion of IgA were initially discovered in 2005, and research to enhance t1xbet 철수 functions of mucosal immunity continues at t1xbet 철수 Otsu Nutraceuticals Research Institute.
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