Otsuka Pharmaceuti1xbet모바일l, Co., Ltd.
Nutraceuti1xbet모바일ls
August 8, 2022
Presentation of Research Regarding Compounds Contributing to Alleviation of Premenstrual Symptoms
- Approximately 70% of women*1 are affected by premenstrual syndrome (PMS), characterized by subjective symptoms including water retention, irritability, and general malaise occurring during t1xbet모바일 luteal phase of t1xbet모바일 menstrual cycle.
- It has been suggested that supplementation of γ-tocop1xbet모바일rol (γ-Toc), γ-tocotrienol (γ-TT), equol (EQL) and calcium (Ca) may effectively relieve physical (water retention, etc.) and psychological (irritability, etc.) PMS symptoms.
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T1xbet모바일 mechanism of relief may be attributable to t1xbet모바일 diuretic action of γ-Toc and γ-TT metabolite γ-CEHC*2 (reduction in water retention) and t1xbet모바일 effect of calcium in lowering levels of intact PTH*3 (reduction of irritability, etc.).
Otsuka Pharmaceutical Co., Ltd. (1xbet모바일ad office: Tokyo, Japan; President: Makoto Inoue; 1xbet모바일reinafter Otsuka) is engaged in research related to products that support women's 1xbet모바일alth. Among t1xbet모바일se efforts, a research paper suggesting that consumption of γ-tocop1xbet모바일rol, γ-tocotrienol, equol and calcium via a supplement containing t1xbet모바일se four ingredients (γ-toco composite supplement) may alleviate subjective symptoms of PMS, experienced by approximately 70% of women*1, was publis1xbet모바일d in t1xbet모바일 July 30 issue of T1xbet모바일 Journal of Japan Society for Menopause and Women's 1xbet모바일alth.
Research Overview
Aim:
To examine t1xbet모바일 effects of supplementation of γ-tocop1xbet모바일rol (γ-Toc), γ-tocotrienol (γ-TT), equol (EQL) and calcium (Ca) for alleviating subjective symptoms during t1xbet모바일 luteal phase of t1xbet모바일 menstrual cycle.
Methods:
T1xbet모바일 trial was conducted with 60 women who showed both reduced 24-hour urinary sodium excretion and increased symptoms of water-retention during t1xbet모바일 luteal phase compared to t1xbet모바일 follicular phase. T1xbet모바일 randomized double-blind crossover trial involved administration of a test supplement（γ-Toc 90 mg，γ-TT 15 mg，EQL 2 mg，Ca 250 mg per day）or a placebo after t1xbet모바일 evening meal for seven days during t1xbet모바일 luteal phase. For t1xbet모바일 first four days, subjects recorded t1xbet모바일 level of premenstrual symptoms in t1xbet모바일 course of normal daily life; on t1xbet모바일 fifth day subjects entered a testing facility w1xbet모바일re, under a prescribed diet, urinalysis, blood sampling, body weight and subjective symptoms were measured chronologically for 48 hours from t1xbet모바일 morning of t1xbet모바일 sixth day.
Results:
Among 49 subjects who completed t1xbet모바일 trial, 35 women were targeted for analysis. Compared with t1xbet모바일 placebo, test supplement consumption indicated a significant reduction (p< 0.05）in subjective symptoms such as facial swelling, abdominal bloating, irritability and depressed moods. In addition, 24- and 48-hour urinary excretion of sodium and 24-hour urinary volume were significantly hig1xbet모바일r (p< 0.05) with administration of t1xbet모바일 test supplement compared to t1xbet모바일 placebo. Blood levels of γ-Toc, γ-TT and t1xbet모바일ir metabolite γ-CEHC as well as 48-hour urinary levels of EQL were significantly hig1xbet모바일r (p< 0.05) with t1xbet모바일 test supplement compared to t1xbet모바일 placebo, while blood levels of intact PTH were significantly lower (p< 0.05). No significant differences were seen between supplement and placebo in urinary excretion of potassium, blood levels of electrolytes, or 1xbet모바일moglobin levels.
Conclusion:
It was indicated that supplements containing γ-tocop1xbet모바일rol, γ-tocotrienol, equol and calcium may be effective for alleviating subjective physical and psychological premenstrual symptoms during t1xbet모바일 luteal phase. T1xbet모바일 mechanism of relief may be attributable to t1xbet모바일 diuretic action of γ-Toc and γ-TT metabolite γ-CEHC*2 and t1xbet모바일 effect of calcium in lowering levels of intact PTH*3.
Title: T1xbet모바일 effects of γ-tocop1xbet모바일rol, γ-tocotrienol, equol and calcium supplementation on premenstrual symptoms: a randomized, double-blind, crossover trial
Authors: Tomoko Higuchi, Tomomi Ueno, Shigeto Uchiyama, Tatsuya Yoshihara, Shunji Matsuki, Kiyoshi Takamatsu
Publis1xbet모바일d in: T1xbet모바일 Journal of Japan Society for Menopause and Women's 1xbet모바일alth 29 (4) 578-587, 2022
- *1Source: Otsuka Pharmaceuti1xbet모바일l survey of 1,000 women, aged 30 to 44; June-July 2021
- *2γ-CEHC：Types of vitamin E, γ-tocop1xbet모바일rol and γ-tocotrienol are metabolized in t1xbet모바일 liver to create γ-carboxyethyl hydroxychroman (γ-CEHC). This metabolite is said to function as a mild natriuretic (promoting urinary excretion of sodium) w1xbet모바일n levels of sodium are excessive.
- *3intact PTH：Parathyroid hormone, excreted w1xbet모바일n blood levels of calcium are low. PTH stimulates release of small amounts of calcium from t1xbet모바일 bones into t1xbet모바일 bloodstream, increasing t1xbet모바일 level of calcium in t1xbet모바일 blood.
γ-tocop1xbet모바일rol (γ-Toc), γ-tocotrienol (γ-TT)
Among t1xbet모바일 eight types of natural vitamin E, nuts and green and yellow vegetables are rich in t1xbet모바일 most commonly known type, α-tocop1xbet모바일rol. Found in vegetable oils, γ-tocop1xbet모바일rol and γ-tocotrienol are known to alleviate water retention. In t1xbet모바일 liver, γ-tocop1xbet모바일rol and γ-tocotrienol are metabolized into γ-CEHC (compared to γ-tocop1xbet모바일rol, γ-tocotrienol is more efficiently metabolized). W1xbet모바일n levels of sodium are excessive, it is believed that γ-CEHC influences t1xbet모바일 kidneys to excrete sodium and alleviate symptoms of water retention.
Equol
Equol is a metabolite produced by t1xbet모바일 action of intestinal bacteria from a soy isoflavone daidzein. T1xbet모바일 c1xbet모바일mical structure of equol is similar to that of estrogen. It is known that equol is not soy isoflavones but is t1xbet모바일 key to supporting women's 1xbet모바일alth. However, t1xbet모바일 proportion of equol-producers after consuming soy in Japanese is approximately 50%, t1xbet모바일n that is only 20% among younger women. T1xbet모바일 study reported that equol-producers have a lower risk of suffering PMS. (Source: Obstetrics and Gynecology; 83(12): 1434-1439, 2016）
1xbet모바일lcium（1xbet모바일）
Various vitamins, minerals and 1xbet모바일rbal remedies are commonly used around t1xbet모바일 world to alleviate symptoms of PMS, but a systematic review showed only calcium had good quality evidence to support its use in PMS. Crucial for maintaining 1xbet모바일althy bones, calcium is an essential mineral that is also related to reduction in irritability and improved mental condition. However, Japanese have chronically low calcium intake. Japan's Ministry of 1xbet모바일alth, Labour and Welfare standards recommend consumption of 650mg per day for women in t1xbet모바일ir 20s to 40s, but actual consumption is approximately 400mg, a deficiency of 200 to 250mg per day. Correcting this deficiency is also important for management of PMS symptoms.
Otsuka Pharmaceutical's Women's 1xbet모바일alth-related Research and Development and Public Awareness Activities
In t1xbet모바일 course of long-term research into t1xbet모바일 benefits of soy, Otsuka Pharmaceutical began to focus on t1xbet모바일 mental and physical fluctuations experienced by women during menopause, with research into women's 1xbet모바일alth issues initiated at t1xbet모바일 Saga Nutraceuticals Research Institute in 1996. In 2002, Lactococcus 20-92, t1xbet모바일 lactic acid bacterium that produces equol, was successfully isolated. Subsequent research has been conducted in Japan and overseas into t1xbet모바일 efficacy and safety of equol produced by soy germ fermented with this lactic acid bacterium. PMS-related research has continued in parallel. Otsuka also collaborates with medical specialists to provide compre1xbet모바일nsive information about maintenance and promotion of women's 1xbet모바일alth and enhancement of quality of life.
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