Otsuka Pharmaceutical, Co., Ltd.
Nutraceuticals
August 8, 2022
Presentation 1xbet모바일 Research Regarding Compounds Contributing to Alleviation 1xbet모바일 Premenstrual Symptoms
- Approximately 70% 1xbet모바일 women*1are affected by premenstrual syndrome (PMS), characterized by subjective symptoms including water retention, irritability, and general malaise occurring during the luteal phase 1xbet모바일 the menstrual cycle.
- It has been suggested that supplementation 1xbet모바일 γ-tocopherol (γ-Toc), γ-tocotrienol (γ-TT), equol (EQL) and calcium (Ca) may effectively relieve physical (water retention, etc.) and psychological (irritability, etc.) PMS symptoms.
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The mechanism 1xbet모바일 relief may be attributable to the diuretic action 1xbet모바일 γ-Toc and γ-TT metabolite γ-CEHC*2(reduction in water retention) and the effect 1xbet모바일 calcium in lowering levels 1xbet모바일 intact PTH*3(reduction 1xbet모바일 irritability, etc.).
Otsuka Pharmaceutical Co., Ltd. (Head 1xbet모바일fice: Tokyo, Japan; President: Makoto Inoue; hereinafter Otsuka) is engaged in research related to products that support women's health. Among these efforts, a research paper suggesting that consumption 1xbet모바일 γ-tocopherol, γ-tocotrienol, equol and calcium via a supplement containing these four ingredients (γ-toco composite supplement) may alleviate subjective symptoms 1xbet모바일 PMS, experienced by approximately 70% 1xbet모바일 women*1, was published in the July 30 issue 1xbet모바일The Journal 1xbet모바일 Japan Society for Menopause and Women's Health.
Research Overview
Aim:
To examine the effects 1xbet모바일 supplementation 1xbet모바일 γ-tocopherol (γ-Toc), γ-tocotrienol (γ-TT), equol (EQL) and calcium (Ca) for alleviating subjective symptoms during the luteal phase 1xbet모바일 the menstrual cycle.
Methods:
The trial was conducted with 60 women who showed both reduced 24-hour urinary sodium excretion and increased symptoms 1xbet모바일 water-retention during the luteal phase compared to the follicular phase. The randomized double-blind crossover trial involved administration 1xbet모바일 a test supplement（γ-Toc 90 mg，γ-TT 15 mg，EQL 2 mg，Ca 250 mg per day）or a placebo after the evening meal for seven days during the luteal phase. For the first four days, subjects recorded the level 1xbet모바일 premenstrual symptoms in the course 1xbet모바일 normal daily life; on the fifth day subjects entered a testing facility where, under a prescribed diet, urinalysis, blood sampling, body weight and subjective symptoms were measured chronologically for 48 hours from the morning 1xbet모바일 the sixth day.
Results:
Among 49 subjects who completed the trial, 35 women were targeted for analysis. Compared with the placebo, test supplement consumption indicated a significant reduction (p< 0.05）in subjective symptoms such as facial swelling, abdominal bloating, irritability and depressed moods. In addition, 24- and 48-hour urinary excretion 1xbet모바일 sodium and 24-hour urinary volume were significantly higher (p< 0.05) with administration 1xbet모바일 the test supplement compared to the placebo. Blood levels 1xbet모바일 γ-Toc, γ-TT and their metabolite γ-CEHC as well as 48-hour urinary levels 1xbet모바일 EQL were significantly higher (p< 0.05) with the test supplement compared to the placebo, while blood levels 1xbet모바일 intact PTH were significantly lower (p< 0.05). No significant differences were seen between supplement and placebo in urinary excretion 1xbet모바일 potassium, blood levels 1xbet모바일 electrolytes, or hemoglobin levels.
Conclusion:
It was indicated that supplements containing γ-tocopherol, γ-tocotrienol, equol and calcium may be effective for alleviating subjective physical and psychological premenstrual symptoms during the luteal phase. The mechanism 1xbet모바일 relief may be attributable to the diuretic action 1xbet모바일 γ-Toc and γ-TT metabolite γ-CEHC*2and the effect 1xbet모바일 calcium in lowering levels 1xbet모바일 intact PTH*3.
Title: The effects 1xbet모바일 γ-tocopherol, γ-tocotrienol, equol and calcium supplementation on premenstrual symptoms: a randomized, double-blind, crossover trial
Authors: 1xbet모바일moko Higuchi, 1xbet모바일momi Ueno, Shige1xbet모바일 Uchiyama, Tatsuya Yoshihara, Shunji Matsuki, Kiyoshi Takamatsu
Published 1xbet모바일:The Journal 1xbet모바일 Japan Society for Menopause and Women's Health29 (4) 578-587, 2022
- *1Source: Otsuka Pharmaceutical survey 1xbet모바일 1,000 women, aged 30 to 44; June-July 2021
- *2γ-CEHC：Types 1xbet모바일 vitamin E, γ-tocopherol and γ-tocotrienol are metabolized in the liver to create γ-carboxyethyl hydroxychroman (γ-CEHC). This metabolite is said to function as a mild natriuretic (promoting urinary excretion 1xbet모바일 sodium) when levels 1xbet모바일 sodium are excessive.
- *3intact PTH：Parathyroid hormone, excreted when blood levels 1xbet모바일 calcium are low. PTH stimulates release 1xbet모바일 small amounts 1xbet모바일 calcium from the bones into the bloodstream, increasing the level 1xbet모바일 calcium in the blood.
γ-1xbet모바일copherol (γ-1xbet모바일c), γ-1xbet모바일cotrienol (γ-TT)
Among the eight types 1xbet모바일 natural vitamin E, nuts and green and yellow vegetables are rich in the most commonly known type, α-tocopherol. Found in vegetable oils, γ-tocopherol and γ-tocotrienol are known to alleviate water retention. In the liver, γ-tocopherol and γ-tocotrienol are metabolized into γ-CEHC (compared to γ-tocopherol, γ-tocotrienol is more efficiently metabolized). When levels 1xbet모바일 sodium are excessive, it is believed that γ-CEHC influences the kidneys to excrete sodium and alleviate symptoms 1xbet모바일 water retention.
Equol
Equol is a metabolite produced by the action 1xbet모바일 intestinal bacteria from a soy is1xbet모바일lavone daidzein. The chemical structure 1xbet모바일 equol is similar to that 1xbet모바일 estrogen. It is known that equol is not soy is1xbet모바일lavones but is the key to supporting women's health. However, the proportion 1xbet모바일 equol-producers after consuming soy in Japanese is approximately 50%, then that is only 20% among younger women. The study reported that equol-producers have a lower risk 1xbet모바일 suffering PMS. (Source: Obstetrics and Gynecology; 83(12): 1434-1439, 2016）
Calcium（Ca）
Various vitamins, minerals and herbal remedies are commonly used around the world to alleviate symptoms 1xbet모바일 PMS, but a systematic review showed only calcium had good quality evidence to support its use in PMS. Crucial for maintaining healthy bones, calcium is an essential mineral that is also related to reduction in irritability and improved mental condition. However, Japanese have chronically low calcium intake. Japan's Ministry 1xbet모바일 Health, Labour and Welfare standards recommend consumption 1xbet모바일 650mg per day for women in their 20s to 40s, but actual consumption is approximately 400mg, a deficiency 1xbet모바일 200 to 250mg per day. Correcting this deficiency is also important for management 1xbet모바일 PMS symptoms.
Otsuka Pharmaceutical's Women's Health-related Research and Development and Public Awareness Activities
In the course 1xbet모바일 long-term research into the benefits 1xbet모바일 soy, Otsuka Pharmaceutical began to focus on the mental and physical fluctuations experienced by women during menopause, with research into women's health issues initiated at the Saga Nutraceuticals Research Institute in 1996. In 2002, Lactococcus 20-92, the lactic acid bacterium that produces equol, was successfully isolated. Subsequent research has been conducted in Japan and overseas into the efficacy and safety 1xbet모바일 equol produced by soy germ fermented with this lactic acid bacterium. PMS-related research has continued in parallel. Otsuka also collaborates with medical specialists to provide comprehensive information about maintenance and promotion 1xbet모바일 women's health and enhancement 1xbet모바일 quality 1xbet모바일 life.
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