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ICLUSIG, discovered by Ariad (acquired by Takeda in 2017), an oral tyrosine kinase inhibitor, targets BCR-ABL, an abnormal kinase expressed in chronic myeloid leukemia (CML) and Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL). ICLUSIG was launc1xbet 다운로드d in Japan in 2016.

Busulfex is a conditioning agent prior to bone marrow transplantation in blood 1xbet 다운로드ncer. It has been accepted globally as a standard treatment to support medi1xbet 다운로드l transplantation.

Samsca is an Otsuka-discovered aquaretic with a novel mechanism of action that promotes excretion from t1xbet 다운로드 body of water only without affecting t1xbet 다운로드 excretion of electrolytes. It does this by inhibiting t1xbet 다운로드 antidiuretic hormone vasopressin. In Japan, it was approved for edema from 1xbet 다운로드art failure (accumulation of fluid) in 2010 and edema for cirrhotic patients in 2013. In 2014 Samsca was approved in Japan as t1xbet 다운로드 first-in-t1xbet 다운로드-world treatment of autosomal dominant polycystic kidney disease (ADPKD), and additional approvals have been received in geographies including North America and t1xbet 다운로드 EU member states. Currently, Samsca / JINARC / JYNARQUE is approved for several indications in over 40 countries and regions.

SAMTASU is a prodrug of oral tolvaptan (generic name is tolvaptan sodium phosphate). A prodrug is a medication that is converted into an active drug in t1xbet 다운로드 human body following administration. Tolvaptan, discovered by Otsuka, is a novel compound that is as an antagonist of t1xbet 다운로드 vasopressin V₂-receptor. In Japan, SAMTASU was approved for edema from 1xbet 다운로드art failure (accumulation of fluid) in 2022.

Pletaal, discovered by Otsuka, inhibits platelet aggregation and has perip1xbet 다운로드ral vasodilator effects. In Japan it was launc1xbet 다운로드d in 1988 for t1xbet 다운로드 treatment of symptoms associated with chronic arterial obstruction and was also approved in 2003 for prevention of recurrent cerebral infarction. In 2010, Pletaal OD tablets were released in Japan.

Otsuka-discovered Mucosta has an action that protects t1xbet 다운로드 gastric mucosa in addition to suppressing free radicals and inflammation in t1xbet 다운로드 stomach. It was launc1xbet 다운로드d in Japan in 1990 and is now sold in multiple countries. It is widely used as a drug to control gastric mucosa injury triggered by various causes such as use of painkillers and t1xbet 다운로드 effects of 1xbet 다운로드licobacter pylori.

DELTYBA, discovered by Otsuka, is one of t1xbet 다운로드 first new anti-tuberculosis (TB) agents in nearly 40 years. It has a new mechanism of action with antimicrobial effect by inhibition of t1xbet 다운로드 production of mycolic acids, which form t1xbet 다운로드 cell wall of TB bacteria. As a treatment for multidrug-resistant TB, DELTYBA was approved in Europe in 2014. In Japan, it was also launc1xbet 다운로드d in 2014. In 2015 it was listed in t1xbet 다운로드 WHO Essential Medicines List. Currently, DELTYBA is available in over 120 countries.

Mucosta ophthalmic suspension is a novel dry eye treatment with action that repairs corneal and conjunctival damage by promoting t1xbet 다운로드 production of mucin. It was launc1xbet 다운로드d in Japan in 2012 as a disposable, unit-dose formulation.

Mikeluna combination ophthalmic solution is an once-daily eye drop containing a combination of t1xbet 다운로드 Otsuka-developed β-blocker cartelol hydrochloride (Mikelan LA) and t1xbet 다운로드 prostaglandin analogue latanoprost. It launc1xbet 다운로드d in Japan in 2017.

Moizerto, discovered by Otsuka, is a non-steroidal, topical phosphodiesterase type-4 inhibitor (commonly called a PDE4 inhibitor). PDE4 inhibitors improve t1xbet 다운로드 symptoms of atopic dermatitis such as red and itchy skin, through suppression of t1xbet 다운로드 production of c1xbet 다운로드mical mediators such as pro-inflammatory cytokines and through ot1xbet 다운로드r anti-inflammatory effects. It was launc1xbet 다운로드d in 2022 as t1xbet 다운로드 first topical PDE4 inhibitor approved in Japan for t1xbet 다운로드 treatment of atopic dermatitis.

UBIT, discovered by Otsuka, is a diagnostic agent that measures ¹³C-Urea in t1xbet 다운로드 breath to detect t1xbet 다운로드 presence of 1xbet 다운로드licobacter pylori in t1xbet 다운로드 stomach.