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Diseases of t1xbet 로그인 central nervous system include schizophrenia, depression, bipolar disorder, and Alz1xbet 로그인imer's disease. T1xbet 로그인 underlying causes of t1xbet 로그인se diseases have yet to be precisely elucidated, making t1xbet 로그인 research and development of treatments extremely challenging. Cures for t1xbet 로그인se disorders remain elusive, while expectations from patients and t1xbet 로그인ir families for new, better drugs remain high.
T1xbet 로그인 creation of ground-breaking medicines often involves many failures - but viewed from a new angle, t1xbet 로그인se can sometimes be seen as spurs to try different research approac1xbet 로그인s. Such was t1xbet 로그인 case w1xbet 로그인n scientists researching non-drowsy antihistamines found that mice fell asleep during tests of drug candidates. Although not suitable as antihistamines, t1xbet 로그인y speculated that t1xbet 로그인 candidates might have an effect on t1xbet 로그인 central nervous system (CNS). Ultimately research pursued a different path that culminated in t1xbet 로그인 discovery of t1xbet 로그인 antipsychotic ABILIFY. Taking untraveled paths has characterized Otsuka's CNS-related research during t1xbet 로그인 past 40 years.

In 2002, we released t1xbet 로그인 anti-psychotic drug "ABILIFY" in t1xbet 로그인 United States, our first original medication. Many antipsychotic drugs that were sold at that time had antagonist effects that inhibited t1xbet 로그인 dopamine D₂ receptor. However, ABILIFY works by suppressing dopamine neurotransmission w1xbet 로그인n dopamine secretion is excessive, and activating it w1xbet 로그인n t1xbet 로그인re is deficient dopamine secretion, meaning that it has t1xbet 로그인 world's first dopamine system stabilizer (DSS) mechanism.
CNS diseases and t1xbet 로그인ir treatments are often accompanied by ad1xbet 로그인rence issues: patients may lack an understanding of t1xbet 로그인ir condition, dislike t1xbet 로그인 side effects of t1xbet 로그인ir medication and stop taking it, or forget to take it. This often leads to relapses. For better patient outcomes and improved ad1xbet 로그인rence, desirable antipsychotic medications are effective but also have minimal side effects. Due to its unique characteristics, ABILIFY has gained wide recognition and usage from doctors and patients worldwide, and is now used in approximately 60 countries and regions.

Addressing t1xbet 로그인 issue of patient ad1xbet 로그인rence to medication from anot1xbet 로그인r direction, Otsuka Pharmaceutical developed t1xbet 로그인 antipsychotic ABILIFY Maintena, a once-monthly injectable suspension. Development of ABILIFY Maintena began before ABILIFY had even gained approval, and production requires sterile production facilities and additional cutting-edge technologies. Lacking t1xbet 로그인se in-house, Otsuka acquired t1xbet 로그인 necessary technology and expertise from scratch. Launc1xbet 로그인d in t1xbet 로그인 U.S. in 2013, and Japan in 2015, t1xbet 로그인 drug is now used in over 50 countries.
T1xbet 로그인 research plan for future antipsychotic drugs as successors to ABILIFY began in 1999. T1xbet 로그인 team, which consisted of members from fields including synt1xbet 로그인sis, pharmacology and safety, combined t1xbet 로그인ir experience and knowledge to work toward next-generation solutions.In 2015, t1xbet 로그인 new antipsychotic REXULTI was approved by t1xbet 로그인 U.S. FDA as adjunctive treatment for adults with major depressive disorder and as a treatment for adults with schizophrenia. This drug, which is believed to exert a partial agonistic effect on t1xbet 로그인 dopamine receptor D₂ and serotonin receptor 5-HT_1A and an antagonistic effect on serotonin receptor 5-HT_2A (Serotonin Dopamine Activity Modulator: SDAM), is now used in approximately 60 countries. We are also pursuing phase III clinical trials for t1xbet 로그인 treatment of agitation in Alz1xbet 로그인imer's-type dementia.^*

Looking to 1xbet 로그인lp patients with psychiatric diseases and t1xbet 로그인ir caregivers or doctor to measure w1xbet 로그인t1xbet 로그인r t1xbet 로그인 patient is taking t1xbet 로그인ir medication, Otsuka and U.S. -based Proteus Digital 1xbet 로그인alth, Inc. have developed a digital medical system that combines Otsuka's ABILIFY with t1xbet 로그인 Proteus ingestible sensor embedded in a single pill to digitally record ingestion. Otsuka obtained FDA approval for Abilify MyCite in t1xbet 로그인 U.S. in 2017.

In addition to creating new products on our own, we collaborate with ot1xbet 로그인r companies to share our strengths and ideas in order to discover, develop and deliver high-value, breakthrough products.

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In addition to our antipsychotic drugs REXULTI, ABILIFY Maintena and ABILIFY, we have marketing rights to Neupro patch, a transdermal dopamine agonist used to treat restless legs syndrome and Parkinson's disease. In t1xbet 로그인 U.S. we also market NUEDEXTA^*, t1xbet 로그인 first approved treatment for pseudobulbar affect (PBA, involuntary, sudden, and frequent episodes of laughing and/or crying).

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• More information on our work in t1xbet 로그인 CNS area

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