1xbet 사기 Pharmaceutical Co., Ltd.
1xbet 사기 Holdings Co., Ltd.

Pharmaceuticals
January 24, 2011

Otsuka Pharmaceutical Files 1xbet 사기 Additional Indication Regulatory Approval in Japan 1xbet 사기 ABILIFY®, a Treatment 1xbet 사기 the Manic Symptoms Associated with Bipolar Disorder

Tokyo, Japan, January 24, 2011 -- Otsuka Pharmaceutical Co., Ltd. today announced that it has applied 1xbet 사기 additional indication regulatory approval in Japan 1xbet 사기 ABILIFY®(aripiprazole), a treatment 1xbet 사기 the manic symptoms associated with bipolar disorder.

Otsuka Pharmaceutical commenced marketing ABILIFY in Japan in June 2006 as a treatment 1xbet 사기 schizophrenia. ABILIFY is currently sold in five 1xbet 사기mulations, ABILIFY Tablets 3 mg, ABILIFY Tablets 6 mg, ABILIFY Tablets 12 mg, ABILIFY Powder 1% and ABILIFY Oral Solution 0.1%.

Bipolar disorder, which is also referred to as manic- depressive psychosis, is said to have a lifetime prevalence of 0.4%*. Symptoms include a repetitive cycle between manic and depressive states. A manic state is defined by 1xbet 사기 presence of abnormally elevated energy levels and impaired judgment. In a large number of cases, 1xbet 사기 individual is unaware of any illness and is unlikely to seek assistance. Signs and symptoms of 1xbet 사기 depressive phase on 1xbet 사기 o1xbet 사기r hand, include strong feelings of despair. Individuals with this condition will oftentimes seek 1xbet 사기 support of o1xbet 사기rs. Unable to accept or deal with 1xbet 사기 reality of 1xbet 사기 situation, depression can also lead to feelings of hopelessness. In 1xbet 사기 case of mixed episodes or states, 1xbet 사기 features of both mania and depression are present at 1xbet 사기 same time. A notable characteristic of bipolar disorder is its high incidence of relapse. Accordingly, it is generally accepted that bipolar disorder requires long-term treatment.
This application 1xbet 사기 additional indication approval is 1xbet 사기 a treatment 1xbet 사기 the manic symptoms associated with bipolar disorder.

  • *Research relating to 1xbet 사기 epidemiological study of health science: Fiscal 2006 Health and Labour Sciences Research Grant (Health Science)

ABILIFY®is described as a dopamine system stabilizer (DSS). It exerts an inhibitory action when large amounts of dopamine are released in the brain and a stimulatory action when only small amounts are released, thus stabilizing dopamine neurons. This mechanism enables the drug to improve both the positive and negative symptoms of schizophrenia which are thought to be induced by dopamine abnormalities. At the same time, the drug can be used 1xbet 사기 long-term continuous treatment as it is less likely to cause drowsiness or weight gain. To date, ABILIFY is sold in 65 countries and regions worldwide including Japan with global sales of approximately 370 billion yen in fiscal 2009.

Based on its corporate philosophy of 'Otsuka-people creating new products 1xbet 사기 better health worldwide,' Otsuka Pharmaceutical is dedicated to contributing to the health of people around the world.