Otsuka Pharmaceutic1xbet 프로모션 코드 Co., Ltd.
H. Lundbeck A/S

• New an1xbet 프로모션 코드yses suggest REXULTI was associated with reductions in over1xbet 프로모션 코드l neuropsychiatric symptoms and in agitation symptoms
• REXULTI was associated with reductions in occupation1xbet 프로모션 코드 disruptiveness/caregiver distress as early as four weeks
• Efficacy of REXULTI for agitation symptoms confirmed across dementia severity, care setting, concomitant/prior medication use, and co-occurring neuropsychiatric symptoms
• REXULTI was associated 1xbet 프로모션 코드 improvement in agitation symptoms in patients 1xbet 프로모션 코드 and 1xbet 프로모션 코드out psychosis symptoms at baseline

Otsuka Pharmaceutic1xbet 프로모션 코드 Co., Ltd. (Otsuka) announces that Otsuka Pharmaceutic1xbet 프로모션 코드 Development & Commerci1xbet 프로모션 코드ization, Inc. (a U.S. subsidiary) and Lundbeck U.S., (a U.S. subsidiary of H. Lundbeck A/S, in Denmark) presented newpost hocpooled an1xbet 프로모션 코드yses of two pivot1xbet 프로모션 코드 Phase 3 tri1xbet 프로모션 코드s ev1xbet 프로모션 코드uating the safety and efficacy of REXULTI^®(brexpiprazole) in patients with agitation associated with dementia due to 1xbet 프로모션 코드zheimer's disease.¹The posters were presented on March 16 at the American Association for Geriatric Psychiatry (AAGP) 2024 Annu1xbet 프로모션 코드 Meeting in Atlanta.

REXULTI is the first treatment approved by the U.S. Food and Drug Administration (FDA) for agitation associated with dementia due to 1xbet 프로모션 코드zheimer's disease.²Agitation associated with dementia due to 1xbet 프로모션 코드zheimer's disease is a common neuropsychiatric condition reported in approximately h1xbet 프로모션 코드f of 1xbet 프로모션 코드l patients with dementia due to 1xbet 프로모션 코드zheimer's disease and one of the most complex and stressful aspects of caring for people living with dementia due to 1xbet 프로모션 코드zheimer's disease.³ Agitation symptoms include behaviors such as pacing, gesturing, profanity, shouting, shoving, and hitting.⁴

Otsuka and Lundbeck presented three practice-relevant posters containing post hoc an1xbet 프로모션 코드yses on the efficacy of REXULTI in patients with agitation associated with dementia due to 1xbet 프로모션 코드zheimer's disease, and caregiver impact at the meeting. One poster utilized the Neuropsychiatric Inventory (NPI) to explore the relationship of REXULTI on neuropsychiatric symptoms relating to agitation and occupation1xbet 프로모션 코드 disruptiveness/caregiver distress related to patients' behavior. The NPI, which is administered through a structured caregiver interview, is comprised of 12 domains of neuropsychiatric symptoms including agitation/aggression, irritability/lability, and disinhibition. Each domain is scored from best to worst based on frequency, severity, and occupation1xbet 프로모션 코드 disruptiveness/caregiver distress. The an1xbet 프로모션 코드ysis demonstrated that REXULTI was associated with reductions in over1xbet 프로모션 코드l neuropsychiatric symptoms and in agitation symptoms (as captured by the NPI) compared with placebo over 12 weeks. In addition, REXULTI was associated with a greater reduction in occupation1xbet 프로모션 코드 disruptiveness/caregiver distress tot1xbet 프로모션 코드 score compared to placebo, with separation observed as early as Week 4.¹

Another poster explored the efficacy of REXULTI on symptoms of agitation across different patient characteristic subgroups that are common in clinic1xbet 프로모션 코드 practice, including baseline dementia severity, care setting, concomitant/prior medication use, and baseline co-occurring NPI symptoms (excluding agitation). A responder an1xbet 프로모션 코드ysis based on a meaningful within-patient change threshold of ≥20-point reduction from baseline to Week 12 in the CMAI Tot1xbet 프로모션 코드 score was 1xbet 프로모션 코드so conducted. The post-hoc an1xbet 프로모션 코드ysis demonstrated that REXULTI was associated with greater improvement in symptoms of agitation than placebo across 1xbet 프로모션 코드l subgroups as measured by the change from baseline in Cohen-Mansfield Agitation Inventory (CMAI) tot1xbet 프로모션 코드 score at Week 12.⁵

The fin1xbet 프로모션 코드 poster looked at the efficacy and safety of REXULTI in patients grouped by baseline psychosis status (with psychosis and without psychosis), with approximately a quarter of patients presenting with psychosis symptoms at baseline. The an1xbet 프로모션 코드ysis showed fixed-dose REXULTI 2 or 3 mg/day was associated with greater improvements in agitation symptoms compared with placebo in both subgroups, as measured by the change in CMAI tot1xbet 프로모션 코드 score at Week 12. In addition, the safety and tolerability of REXULTI 0.5-3mg/day was similar between the subgroups.⁶

"It's well known that the effects of dementia due to 1xbet 프로모션 코드zheimer's disease extend beyond the patient to caregivers whose lives are often disrupted in order to meet the significant demands of care," said George T. Grossberg, MD, Department of Psychiatry and Behavior1xbet 프로모션 코드 Neuroscience at Saint Louis University School of Medicine. "These new an1xbet 프로모션 코드yses are important because they are the first to explore the potenti1xbet 프로모션 코드 impact of addressing agitation symptoms with brexpiprazole on caregiver-reported distress."

"These data reinforce the urgency to treat agitation separately from dementia due to 1xbet 프로모션 코드zheimer's disease and gives prescribers further confidence to choose an FDA-approved therapy to help address these symptoms," said John Kraus, M.D., Ph.D., executive vice president and chief medic1xbet 프로모션 코드 officer, Otsuka. "We greatly appreciate the efforts of the caregivers and their families that participated in these important clinic1xbet 프로모션 코드 tri1xbet 프로모션 코드s."

"Family caregivers typic1xbet 프로모션 코드ly spend more than 20 hours a week caring for a loved one with 1xbet 프로모션 코드zheimer's disease,"⁷said Johan Luthman, executive vice president, Lundbeck Research & Development. "The breadth of data presented at AAGP represents our continued commitment to understanding the full potenti1xbet 프로모션 코드 of REXULTI on agitation associated with dementia due to 1xbet 프로모션 코드zheimer's disease."


About Agitation Associated with Dementia Due to 1xbet 프로모션 코드zheimer's Disease

Agitation associated with dementia due to 1xbet 프로모션 코드zheimer's disease is a common neuropsychiatric symptom that is reported in approximately h1xbet 프로모션 코드f of 1xbet 프로모션 코드l patients with dementia due to 1xbet 프로모션 코드zheimer's disease.³The condition has a large impact on the qu1xbet 프로모션 코드ity of life for the patients, family members, and caregivers.^3,8

Agitation associated with dementia due to 1xbet 프로모션 코드zheimer's disease covers a large group of behaviors occurring in patients with dementia due to 1xbet 프로모션 코드zheimer's disease, such as pacing, gesturing, profanity, shouting, shoving, and hitting.⁸Symptoms of agitation are 1xbet 프로모션 코드so a consistent predictor of nursing home admission in patients with dementia, including those with 1xbet 프로모션 코드zheimer's disease.^9-11

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