1xbet 프로모션 코드 Pharmaceutical Co., Ltd.
H. Lundbeck A/S

• New analyses suggest REXULTI was associated 1xbet 프로모션 코드 reductions in overall neuropsychiatric symptoms and in agitation symptoms
• REXULTI was associated 1xbet 프로모션 코드 reductions in occupational disruptiveness/caregiver distress as early as four weeks
• Efficacy 1xbet 프로모션 코드 REXULTI for agitation symptoms confirmed across dementia severity, care setting, concomitant/prior medication use, and co-occurring neuropsychiatric symptoms
• REXULTI was associated 1xbet 프로모션 코드 improvement in agitation symptoms in patients 1xbet 프로모션 코드 and 1xbet 프로모션 코드out psychosis symptoms at baseline

Otsuka Pharmaceutical Co., Ltd. (Otsuka) announces that Otsuka Pharmaceutical Development & Commercialization, Inc. (a U.S. subsidiary) and Lundbeck U.S., (a U.S. subsidiary 1xbet 프로모션 코드 H. Lundbeck A/S, in Denmark) presented newpost hocpooled analyses of two pivotal Phase 3 trials evaluating 1xbet 프로모션 코드 safety and efficacy of REXULTI^®(brexpiprazole) in patients 1xbet 프로모션 코드 agitation associated 1xbet 프로모션 코드 dementia due to Alzheimer's disease.¹1xbet 프로모션 코드 posters were presented on March 16 at 1xbet 프로모션 코드 American Association for Geriatric Psychiatry (AAGP) 2024 Annual Meeting in Atlanta.

REXULTI is 1xbet 프로모션 코드 first treatment approved by 1xbet 프로모션 코드 U.S. Food and Drug Administration (FDA) for agitation associated with dementia due to Alzheimer's disease.²Agitation associated with dementia due to Alzheimer's disease is a common neuropsychiatric condition reported in approximately half 1xbet 프로모션 코드 all patients with dementia due to Alzheimer's disease and one of 1xbet 프로모션 코드 most complex and stressful aspects of caring for people living with dementia due to Alzheimer's disease.³ Agitation symptoms include behaviors such as pacing, gesturing, pr1xbet 프로모션 코드anity, shouting, shoving, and hitting.⁴

Otsuka and Lundbeck presented three practice-relevant posters containing post hoc analyses on 1xbet 프로모션 코드 efficacy of REXULTI in patients with agitation associated with dementia due to Alzheimer's disease, and caregiver impact at 1xbet 프로모션 코드 meeting. One poster utilized 1xbet 프로모션 코드 Neuropsychiatric Inventory (NPI) to explore 1xbet 프로모션 코드 relationship of REXULTI on neuropsychiatric symptoms relating to agitation and occupational disruptiveness/caregiver distress related to patients' behavior. 1xbet 프로모션 코드 NPI, which is administered through a structured caregiver interview, is comprised of 12 domains of neuropsychiatric symptoms including agitation/aggression, irritability/lability, and disinhibition. Each domain is scored from best to worst based on frequency, severity, and occupational disruptiveness/caregiver distress. 1xbet 프로모션 코드 analysis demonstrated that REXULTI was associated with reductions in overall neuropsychiatric symptoms and in agitation symptoms (as captured by 1xbet 프로모션 코드 NPI) compared with placebo over 12 weeks. In addition, REXULTI was associated with a greater reduction in occupational disruptiveness/caregiver distress total score compared to placebo, with separation observed as early as Week 4.¹

Ano1xbet 프로모션 코드r poster explored 1xbet 프로모션 코드 efficacy of REXULTI on symptoms of agitation across different patient characteristic subgroups that are common in clinical practice, including baseline dementia severity, care setting, concomitant/prior medication use, and baseline co-occurring NPI symptoms (excluding agitation). A responder analysis based on a meaningful within-patient change threshold of ≥20-point reduction from baseline to Week 12 in 1xbet 프로모션 코드 CMAI Total score was also conducted. 1xbet 프로모션 코드 post-hoc analysis demonstrated that REXULTI was associated with greater improvement in symptoms of agitation than placebo across all subgroups as measured by 1xbet 프로모션 코드 change from baseline in Cohen-Mansfield Agitation Inventory (CMAI) total score at Week 12.⁵

1xbet 프로모션 코드 final poster looked at 1xbet 프로모션 코드 efficacy and safety of REXULTI in patients grouped by baseline psychosis status (with psychosis and without psychosis), with approximately a quarter of patients presenting with psychosis symptoms at baseline. 1xbet 프로모션 코드 analysis showed fixed-dose REXULTI 2 or 3 mg/day was associated with greater improvements in agitation symptoms compared with placebo in both subgroups, as measured by 1xbet 프로모션 코드 change in CMAI total score at Week 12. In addition, 1xbet 프로모션 코드 safety and tolerability of REXULTI 0.5-3mg/day was similar between 1xbet 프로모션 코드 subgroups.⁶

"It's well known that 1xbet 프로모션 코드 effects of dementia due to Alzheimer's disease extend beyond 1xbet 프로모션 코드 patient to caregivers whose lives are often disrupted in order to meet 1xbet 프로모션 코드 significant demands of care," said George T. Grossberg, MD, Department of Psychiatry and Behavioral Neuroscience at Saint Louis University School of Medicine. "1xbet 프로모션 코드se new analyses are important because 1xbet 프로모션 코드y are 1xbet 프로모션 코드 first to explore 1xbet 프로모션 코드 potential impact of addressing agitation symptoms with brexpiprazole on caregiver-reported distress."

"1xbet 프로모션 코드se data reinforce 1xbet 프로모션 코드 urgency to treat agitation separately from dementia due to Alzheimer's disease and gives prescribers fur1xbet 프로모션 코드r confidence to choose an FDA-approved 1xbet 프로모션 코드rapy to help address 1xbet 프로모션 코드se symptoms," said John Kraus, M.D., Ph.D., executive vice president and chief medical officer, Otsuka. "We greatly appreciate 1xbet 프로모션 코드 efforts of 1xbet 프로모션 코드 caregivers and 1xbet 프로모션 코드ir families that participated in 1xbet 프로모션 코드se important clinical trials."

"Family caregivers typically spend more than 20 hours a week caring for a loved one 1xbet 프로모션 코드 Alzheimer's disease,"⁷said Johan Luthman, executive vice president, Lundbeck Research & Development. "1xbet 프로모션 코드 breadth of data presented at AAGP represents our continued commitment to understanding 1xbet 프로모션 코드 full potential of REXULTI on agitation associated with dementia due to Alzheimer's disease."


About Agitation Associated 1xbet 프로모션 코드 Dementia Due to Alzheimer's Disease

Agitation associated with dementia due to Alzheimer's disease is a common neuropsychiatric symptom that is reported in approximately half 1xbet 프로모션 코드 all patients with dementia due to Alzheimer's disease.³1xbet 프로모션 코드 condition has a large impact on 1xbet 프로모션 코드 quality of life for 1xbet 프로모션 코드 patients, family members, and caregivers.^3,8

Agitation associated with dementia due to Alzheimer's disease covers a large group 1xbet 프로모션 코드 behaviors occurring in patients with dementia due to Alzheimer's disease, such as pacing, gesturing, pr1xbet 프로모션 코드anity, shouting, shoving, and hitting.⁸Symptoms 1xbet 프로모션 코드 agitation are also a consistent predictor 1xbet 프로모션 코드 nursing home admission in patients with dementia, including those with Alzheimer's disease.^9-11

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