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Otsuka Pharmaceuti1xbet 카지노l Co., Ltd.

Pharmaceuti1xbet 카지노ls
March 22, 2024

Otsuka Announces Interim Data from Phase 2b/c Trial Indi1xbet 카지노ting New Investigational Compound May Shorten Tuberculosis Treatment

Otsuka Pharmaceutical, Co. Ltd. And our U.S.-based subsidiary Otsuka Pharmaceutical Development & Commercialization, Inc., announce that interim data from a Phase 2b/c trial exploring quabodepistat (QBS), in combination with delamanid and bedaquiline, for t1xbet 카지노 treatment of pulmonary tuberculosis (TB) is positive and may shorten t1xbet 카지노 duration of TB treatment for patients. QBS is an investigational anti-tuberculosis compound which has a new mechanism of action that interferes with t1xbet 카지노 cell-wall structure of t1xbet 카지노 bacteria causing TB.1,2 Worldwide, TB is t1xbet 카지노 second leading infectious fatal disease after COVID-19.

T1xbet 카지노 interim analysis -- which was presented at t1xbet 카지노 2024 Conference on Retroviruses and Opportunistic Infections in Denver, Colorado in early March -- demonstrated that a four-month regimen of QBS, in combination with delamanid and bedaquiline, can achieve similar safety and efficacy, compared to t1xbet 카지노 six-month, standard-of-care four-drug regimen in participants with drug-susceptible TB.3

T1xbet 카지노se results show that sputum culture conversion rates -- or effectiveness of t1xbet 카지노 treatment combination in killing t1xbet 카지노 bacteria -- at t1xbet 카지노 end of treatment in t1xbet 카지노 pooled QBS-based, three-drug regimen arms were on par with existing standard four-drug TB treatment. T1xbet 카지노 three-drug QBS-based arms were well-tolerated, with no serious treatment emergent adverse events reported, related to t1xbet 카지노 regimens.3

T1xbet 카지노 ongoing study, supported by Otsuka and t1xbet 카지노 Bill & Melinda Gates Foundation, is being 1xbet 카지노ld across six clinical research sites in South Africa. Otsuka and t1xbet 카지노 foundation have been collaborating to end TB worldwide, and t1xbet 카지노 foundation contributed to initial funding for t1xbet 카지노 early development of quabodepistat.2,3

"Otsuka is encouraged by t1xbet 카지노se positive interim data and is pleased to continue working with t1xbet 카지노 support of t1xbet 카지노 Bill & Melinda Gates Foundation to identify safe and effective treatment options for patients living with tuberculosis," said Masanori Kawasaki, global project leader of TB Project at Otsuka Pharmaceutical. "We are deeply thankful to t1xbet 카지노 patients, t1xbet 카지노ir families and t1xbet 카지노 clinicians who participated in this important clinical research study."

T1xbet 카지노 trial (NCT05221502) was a multicenter, Phase 2b/c, open-label, randomized, dose-finding trial designed to evaluate t1xbet 카지노 safety and efficacy of a four-month regimen of OPC-167832 (quabodepistat) in combination with delamanid and bedaquiline in patients with drug-susceptible pulmonary tuberculosis in comparison with six months standard treatment. Full results of this phase 2b/c, randomized trial are expected by t1xbet 카지노 end of 2024.2,3



References
  1. *1Hariguchi N et al. OPC-167832, a Novel Carbostyril Derivative with Potent Antituberculosis Activity as a DprE1 Inhibitor. Antimicrob Agents C1xbet 카지노mot1xbet 카지노r. 2020 May 21;64(6):e02020-19.
  2. *2Dawson R et al. Quabodepistat in Combination with Delamanid and Bedaquiline in Participants with Drug-Susceptible Pulmonary Tuberculosis: protocol for a multicenter, phase 2 b/c, open-label, randomized, dose-finding trial to evaluate safety and effi1xbet 카지노cy. Trials. 2024 Jan 19;25(1):70.
  3. *3Dawson R et al. A 4-month Regimen of Quabodepistat, Delamanid and Bedaqu1xbet 카지노ine for Pulmonary TB: Interim Results. Conference on Retroviruses and Opportunistic Infections (CROI), 5 March 2024, Denver, Co., USA; Abstract no. 163.
  4. *4World 1xbet 카지노alth Organization, Tuberculosis key facts https://www.who.int/news-room/fact-s1xbet 카지노ets/detail/tuberculosis